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A23187（钙霉素）类似物的半合成。II. 在苯并恶唑环上引入甲基。

Semisynthesis of A23187 (calcimycin) analogs. II. Introduction of a methyl group on the benzoxazole ring.

作者信息

Prudhomme M, Dauphin G, Guyot J, Jeminet G

出版信息

J Antibiot (Tokyo). 1984 Jun;37(6):627-34. doi: 10.7164/antibiotics.37.627.

DOI:10.7164/antibiotics.37.627
PMID:6430853
Abstract

Semisynthesis of two demethylamino A23187 with a methyl group in the 4- or 5-position on the benzene ring were carried out via the cleavage of A23187 oxazole ring and rebuilding of modified benzoxazoles. These compounds were shown to release Ca++ and MG++ from mitochondria and to keep part the antibacterial activity of the natural metabolite.

摘要

通过裂解A23187恶唑环并重建修饰的苯并恶唑，对苯环4位或5位带有甲基的两种去甲基氨基A23187进行了半合成。这些化合物显示可从线粒体释放Ca++和Mg++，并保留天然代谢产物的部分抗菌活性。

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