乌苯美司增强小鼠移植物抗宿主反应及迟发型皮肤超敏反应。
Enhancement of graft-versus-host reaction and delayed cutaneous hypersensitivity in mice by ubenimex.
作者信息
Abe F, Hayashi M, Horinishi H, Matsuda A, Ishizuka M, Umezawa H
出版信息
J Antibiot (Tokyo). 1986 Aug;39(8):1172-7. doi: 10.7164/antibiotics.39.1172.
The effect of ubenimex on graft-versus-host reaction and delayed cutaneous hypersensitivity in mice was studied. Ubenimex enhanced the graft-versus-host reaction in a dose range from 0.005 to 0.5 mg/kg. Ubenimex inhibited the aging-caused decrease of delayed cutaneous hypersensitivity to oxazolone and the efficacy was greater with older mice. Ubenimex also inhibited mitomycin C and L1210-caused decreases of delayed cutaneous hypersensitivity to picryl chloride. However, the excess decrease caused by mitomycin C was not significantly altered by ubenimex.
研究了乌苯美司对小鼠移植物抗宿主反应及迟发型皮肤超敏反应的影响。乌苯美司在0.005至0.5mg/kg的剂量范围内增强了移植物抗宿主反应。乌苯美司抑制了衰老导致的对恶唑酮迟发型皮肤超敏反应的降低，且对老年小鼠的效果更佳。乌苯美司还抑制了丝裂霉素C和L1210导致的对苦味酸氯迟发型皮肤超敏反应的降低。然而，丝裂霉素C引起的过度降低未被乌苯美司显著改变。
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