Bicker U, Pahlke W
J Immunopharmacol. 1985;7(1):127-39. doi: 10.3109/08923978509026474.
A local graft versus host reaction between lymphocytes of Balb-c mice and its F-1-generation CB6F1 can be induced because of differences in products of the class II of the major histocompatibility complex (Ir). In this local mixed lymphocyte reaction mainly T-helper cells and B-cells are involved. An induction of a delayed type hypersensitivity reaction with oxazolon significantly decreases the local graft versus host reaction. Cyclosporin A depresses the local graft versus host reaction and the delayed type hypersensitivity in mice whereas Ciamexone, a 2-cyanaziridine derivative, very selectively only suppresses the local graft versus host reaction and increases the delayed type hypersensitivity.
由于主要组织相容性复合体（Ir）Ⅱ类产物存在差异，可诱导Balb - c小鼠淋巴细胞与其F - 1代CB6F1之间发生局部移植物抗宿主反应。在这种局部混合淋巴细胞反应中，主要涉及T辅助细胞和B细胞。用恶唑酮诱导迟发型超敏反应可显著降低局部移植物抗宿主反应。环孢素A可抑制小鼠的局部移植物抗宿主反应和迟发型超敏反应，而2 - 氰基氮丙啶衍生物Ciamexone则非常选择性地仅抑制局部移植物抗宿主反应，并增强迟发型超敏反应。
