Swidergall Marc
Division of Infectious Diseases, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Institute for Infection and Immunity, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Pathogens. 2019 Mar 25;8(1):40. doi: 10.3390/pathogens8010040.
Over the last decades, fungal infections have emerged as a growing threat to human health. Although the human body is at potential risk, various body sites host several commensal fungal species, including . In healthy individuals, colonizes different mucosal surfaces without causing harm, while under diverse circumstances the fungus can proliferate and cause disease. In this context, the understanding of host⁻ interactions in health and during infection may lead to novel therapeutic approaches. Importantly, host cells express pattern recognition receptors (PRRs), which sense conserved fungal structures and orchestrate innate immune responses. Herein, important findings on the topic of the recognition of at host barrier sites are discussed. This review briefly summarizes the importance and functions of myeloid PRRs, reviews the fungal recognition and biology of stromal cells, and highlights important virulence attributes during site-specific proliferation and invasion.
在过去几十年中，真菌感染已成为对人类健康日益严重的威胁。尽管人体存在潜在风险，但各个身体部位都有多种共生真菌物种，包括……在健康个体中，……定殖于不同的粘膜表面而不造成伤害，而在不同情况下，真菌会增殖并引发疾病。在此背景下，了解健康状态及感染期间宿主与真菌的相互作用可能会带来新的治疗方法。重要的是，宿主细胞表达模式识别受体（PRR），这些受体能够感知保守的真菌结构并协调先天性免疫反应。本文讨论了在宿主屏障部位识别……这一主题的重要发现。本综述简要总结了髓系PRR的重要性和功能，回顾了基质细胞对真菌的识别及生物学特性，并强调了……在特定部位增殖和侵袭过程中的重要毒力属性。
