Glassman J N, Darko D, Gillin J C
J Clin Psychiatry. 1986 Oct;47(10):523-4.
A 39-year-old man with schizoaffective disorder experienced somnambulism only when taking a combination of lithium carbonate, chlorpromazine, triazolam, and benztropine. This was confirmed in the sleep laboratory. The sleepwalking occurred during Stage 2 sleep; the sleep record showed a marked paucity of REM sleep. The patient's brother had had one episode of somnambulism, also following exposure to a substance affecting the CNS. A role for CNS-active medications in triggering some pathologic sleep phenomena in predisposed individuals is hypothesized. Medications with central anticholinergic activity may be particularly important.
一名患有分裂情感障碍的39岁男性仅在服用碳酸锂、氯丙嗪、三唑仑和苯海索的组合药物时出现梦游。这在睡眠实验室得到了证实。梦游发生在浅睡眠2期；睡眠记录显示快速眼动睡眠明显减少。患者的兄弟也曾有过一次梦游发作，也是在接触了一种影响中枢神经系统的物质之后。据推测，中枢神经系统活性药物在易患个体中触发某些病理性睡眠现象方面起到了作用。具有中枢抗胆碱能活性的药物可能尤为重要。
