School of Molecular and Life Sciences, Faculty of Science and Engineering, Curtin University, Perth, WA 6845, Australia.
School of Public Health, Faculty of Health Sciences, Curtin University, Perth, WA 6845, Australia.
Nutrients. 2019 Mar 27;11(4):717. doi: 10.3390/nu11040717.
Raised blood lipid levels are associated with a risk of a cardiovascular disease (CVD). Moderate reductions in several CVD factors such as total, low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol concentrations may be more effective in reducing overall risk than a major reduction in just one. A blind, randomised controlled trial was conducted with 120 healthy overweight (BMI 25⁻30) adults aged 25⁻70 years who were non-smokers, not diabetic and of low risk of cardiovascular disease, as assessed by the Framingham risk equation. Participants consumed 4.5 g PolyGlycopleX (PGX) as softgel capsules (PGXS) or 5 g PGX granules (PGXG) or 5 g rice flour (RF) with meals three times a day for 12 weeks. Total, LDL and non-HDL cholesterol were all significantly reduced (-6%, -5% and -3.5%, respectively) post the PGX granule treatment; however, PGX in softgel capsule form did not affect blood lipid profiles. Daily consumption of PGX granules in overweight low CVD risk adults produced lipid changes indicating a CVD preventative benefit.
血脂水平升高与心血管疾病（CVD）风险相关。多项 CVD 风险因素（如总胆固醇、低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇浓度）适度降低，可能比仅一项因素大幅降低更能有效降低总体风险。一项盲法、随机对照试验纳入了 120 名健康超重（BMI 25-30）、年龄 25-70 岁、不吸烟、无糖尿病且心血管疾病风险低（根据弗雷明汉风险方程评估）的成年人。参与者每日三餐随餐服用 4.5 克聚葡萄糖（PGX）软胶囊（PGXS）或 5 克 PGX 颗粒（PGXG）或 5 克米粉（RF），持续 12 周。PGX 颗粒治疗后，总胆固醇、LDL 胆固醇和非 HDL 胆固醇均显著降低（分别降低了-6%、-5%和-3.5%）；然而，PGX 软胶囊形式对血脂谱没有影响。超重且 CVD 风险低的成年人每日食用 PGX 颗粒可使血脂发生变化，表明具有预防 CVD 的益处。
