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1-月桂精-3-棕榈酸酯作为固体脂质颗粒的新型基质：与单硬脂酸甘油酯和三棕榈酸甘油酯相比，百里香酚的负载量更高，分散体稳定性更好。

1-Laurin-3-Palmitin as a Novel Matrix of Solid Lipid Particles: Higher Loading Capacity of Thymol and Better Stability of Dispersions Than Those of Glyceryl Monostearate and Glyceryl Tripalmitate.

作者信息

Shi Hao, Huang Shuangshuang, He Junbo, Han Lijuan, Zhang Weinong, Zhong Qixin

机构信息

Key Laboratory for Deep Processing of Major Grain and Oil, Ministry of Education, College of Food Science & Engineering, Wuhan Polytechnic University, Wuhan 430023, China.

Hubei Key Laboratory for Processing and Transformation of Agricultural Products, Wuhan Polytechnic University, Wuhan 430023, China.

出版信息

Nanomaterials (Basel). 2019 Mar 29;9(4):489. doi: 10.3390/nano9040489.

DOI:10.3390/nano9040489
PMID:30934814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6523428/
Abstract

To develop solid lipid nanoparticles (SLNs) with a new lipid matrix for delivery of hydrophobic bioactive molecules, high purity 1-laurin-3-palmitin (1,3-LP) was synthesized and the prepared 1,3-LP SLNs were compared with those of two common SLN matrices in glyceryl monostearate (GMS) and glyceryl tripalmitate (PPP). Conditions of preparing SLNs were first optimized by evaluating the particle size, polydispersity index (PDI), zeta-potential, and stability. Thereafter, the performance of SLN loading of a model compound in thymol was studied. The loading capacity of thymol in 1,3-LP SLNs was 16% of lipids and higher than 4% and 12% for GMS- and PPP-SLNs, respectively. The 1,3-LP SLNs also had the best efficiency to entrapment thymol during the prolonged storage. X-ray diffraction (XRD) analyses confirmed the excellent crystalline stability of 1,3-LP leading to the stable entrapment efficiency and better stability of thymol-loaded SLNs. Conversely, the polymorphic transformation of GMS and PPP resulted in the declined entrapment efficiency of thymol in the corresponding SLNs. This work indicated the 1,3-diacylglycerol (DAG) SLNs could be used as a promising delivery system for the encapsulation of hydrophobic bioactive molecules with high loading capacity and stability.

摘要

为了开发一种用于递送疏水性生物活性分子的新型脂质基质的固体脂质纳米粒（SLNs），合成了高纯度的1-月桂酸-3-棕榈酸甘油酯（1,3-LP），并将制备的1,3-LP SLNs与两种常见的SLN基质单硬脂酸甘油酯（GMS）和三棕榈酸甘油酯（PPP）的SLNs进行比较。首先通过评估粒径、多分散指数（PDI）、ζ电位和稳定性来优化SLNs的制备条件。此后，研究了模型化合物百里酚在SLN中的负载性能。百里酚在1,3-LP SLNs中的负载量为脂质的16%，分别高于GMS-SLNs和PPP-SLNs的4%和12%。1,3-LP SLNs在长期储存过程中对百里酚的包封效率也最佳。X射线衍射（XRD）分析证实了1,3-LP具有优异的结晶稳定性，从而导致载百里酚SLNs具有稳定的包封效率和更好的稳定性。相反，GMS和PPP的多晶型转变导致相应SLNs中百里酚的包封效率下降。这项工作表明，1,3-二酰基甘油（DAG）SLNs可作为一种有前景的递送系统，用于封装具有高负载能力和稳定性的疏水性生物活性分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/c51927c74598/nanomaterials-09-00489-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/b1ca149f5415/nanomaterials-09-00489-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/bad97c7a704d/nanomaterials-09-00489-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/a2623e4b7018/nanomaterials-09-00489-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/d177522a9c43/nanomaterials-09-00489-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/be8cbe0246b1/nanomaterials-09-00489-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/5645361b2c49/nanomaterials-09-00489-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/c72abe12d66f/nanomaterials-09-00489-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/12f19a041c4b/nanomaterials-09-00489-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/c51927c74598/nanomaterials-09-00489-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/b1ca149f5415/nanomaterials-09-00489-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/bad97c7a704d/nanomaterials-09-00489-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/a2623e4b7018/nanomaterials-09-00489-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/d177522a9c43/nanomaterials-09-00489-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/be8cbe0246b1/nanomaterials-09-00489-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/5645361b2c49/nanomaterials-09-00489-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/c72abe12d66f/nanomaterials-09-00489-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/12f19a041c4b/nanomaterials-09-00489-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caee/6523428/c51927c74598/nanomaterials-09-00489-g009.jpg

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