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通过包封于固体脂质纳米粒实现汉黄芩素对乳腺癌细胞的持续细胞毒性作用

Sustained Cytotoxicity of Wogonin on Breast Cancer Cells by Encapsulation in Solid Lipid Nanoparticles.

作者信息

Baek Jong-Suep, Na Young-Guk, Cho Cheong-Weon

机构信息

College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea.

出版信息

Nanomaterials (Basel). 2018 Mar 13;8(3):159. doi: 10.3390/nano8030159.

DOI:10.3390/nano8030159
PMID:29533979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5869650/
Abstract

While wogonin has been known to have cytotoxicity against various cancer cells, its bioavailability and cytotoxicity are low due to its low water solubility. Therefore, wogonin-loaded solid lipid nanoparticles were fabricated using a hot-melted evaporation technique. The highest solubility of wogonin was observed in stearic acid. Hence, wogonin-loaded solid lipid nanoparticles were composed of stearic acid as the lipid matrix. The physicochemical properties of the wogonin-loaded solid lipid nanoparticles were evaluated by dynamic laser scattering and scanning electron microscopy. The wogonin-loaded solid lipid nanoparticles exhibited sustained and controlled release up to 72 h. In addition, it was observed that the wogonin-loaded solid lipid nanoparticles exhibited enhanced cytotoxicity and inhibited poly (ADP-ribose) polymerase in MCF-7 breast cancer cells. Overall, the results indicate that wogonin-loaded solid lipid nanoparticles could be an efficient delivery system for the treatment of breast cancer.

摘要

虽然已知汉黄芩素对多种癌细胞具有细胞毒性，但其生物利用度和细胞毒性较低，因为其水溶性较差。因此，采用热熔蒸发技术制备了载汉黄芩素固体脂质纳米粒。汉黄芩素在硬脂酸中的溶解度最高。因此，载汉黄芩素固体脂质纳米粒以硬脂酸为脂质基质组成。通过动态激光散射和扫描电子显微镜对载汉黄芩素固体脂质纳米粒的理化性质进行了评估。载汉黄芩素固体脂质纳米粒在长达72小时内呈现出持续和可控的释放。此外，观察到载汉黄芩素固体脂质纳米粒在MCF-7乳腺癌细胞中表现出增强的细胞毒性并抑制聚（ADP-核糖）聚合酶。总体而言，结果表明载汉黄芩素固体脂质纳米粒可能是一种用于治疗乳腺癌的有效递送系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/dfa75ace4567/nanomaterials-08-00159-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/bb03005ee57c/nanomaterials-08-00159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/c1c08dad813e/nanomaterials-08-00159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/33308aa1db4e/nanomaterials-08-00159-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/173a05e7be2d/nanomaterials-08-00159-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/885cbb40d1a6/nanomaterials-08-00159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/53373ad0e78d/nanomaterials-08-00159-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/5cf817543b9a/nanomaterials-08-00159-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/dfa75ace4567/nanomaterials-08-00159-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/bb03005ee57c/nanomaterials-08-00159-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/c1c08dad813e/nanomaterials-08-00159-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/33308aa1db4e/nanomaterials-08-00159-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/173a05e7be2d/nanomaterials-08-00159-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/885cbb40d1a6/nanomaterials-08-00159-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/53373ad0e78d/nanomaterials-08-00159-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/5cf817543b9a/nanomaterials-08-00159-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9a6/5869650/dfa75ace4567/nanomaterials-08-00159-g008.jpg

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