Brooks D J, Beaney R P, Thomas D G, Marshall J, Jones T
J Cereb Blood Flow Metab. 1986 Oct;6(5):529-35. doi: 10.1038/jcbfm.1986.98.
Regional cerebral pH (rpH) was measured in 12 patients with cerebral tumours and in 5 normal subjects using continuous inhalation of 11CO2 and positron emission tomography (PET). Cerebral tumours with a disrupted blood-brain barrier (BBB) on computed tomography scanning had a similar rpH to that of equivalent regions of contralateral brain tissue (mean tumour rpH, 6.98; mean contralateral brain pH, 6.99). Cerebral tumours with an intact BBB were consistently found to be more alkaline than contralateral brain tissue (mean tumour rpH, 7.09). There was no significant difference between the mean rpH values obtained for peripheral cortical gray and central white matter in normal subjects (7.02 and 6.98, respectively). It is concluded that in spite of reports of raised levels of aerobic glycolysis in neoplastic tissue, there is no evidence that cerebral tumour rpH values are depressed.
使用连续吸入(^{11}CO_2)和正电子发射断层扫描（PET）技术，对12例脑肿瘤患者和5名正常受试者的局部脑pH值（rpH）进行了测量。计算机断层扫描显示血脑屏障（BBB）破坏的脑肿瘤，其rpH与对侧脑组织相应区域相似（肿瘤平均rpH为6.98；对侧脑平均pH为6.99）。一致发现血脑屏障完整的脑肿瘤比侧脑组织碱性更强（肿瘤平均rpH为7.09）。正常受试者外周皮质灰质和中央白质的平均rpH值之间无显著差异（分别为7.02和6.98）。得出的结论是，尽管有报道称肿瘤组织中有氧糖酵解水平升高，但没有证据表明脑肿瘤的rpH值会降低。
