使用[11C]二甲基亚砜和正电子发射断层扫描技术在体内测量脑肿瘤pH值。
In vivo measurement of brain tumor pH using [11C]DMO and positron emission tomography.
作者信息
Rottenberg D A, Ginos J Z, Kearfott K J, Junck L, Dhawan V, Jarden J O
出版信息
Ann Neurol. 1985 Jan;17(1):70-9. doi: 10.1002/ana.410170116.
In vivo measurements of regional brain tissue/tumor pH (rpH) have been accomplished in 9 patients with primary or metastatic brain tumors using [11C]dimethyloxazolidinedione [( 11C]DMO) and positron emission tomography. Tumor rpH values ranged from 6.88 to 7.26, whereas gray matter and white matter rpH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our results, which are consistent with reported [14C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more "acidic" than that of normal gray or white matter.
利用[11C]二甲基恶唑烷二酮([11C]DMO)和正电子发射断层扫描技术，对9例原发性或转移性脑肿瘤患者进行了局部脑组织/肿瘤pH值(rpH)的体内测量。肿瘤rpH值范围为6.88至7.26，而灰质和白质rpH值分别为6.74至7.09和6.77至7.03。我们的结果与已报道的脑和肿瘤pH值的[14C]DMO放射自显影测量结果一致，表明脑肿瘤的pH微环境并不比正常灰质或白质更“酸性”。
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