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红斑狼疮和类风湿关节炎治疗中患者对抗疟药的看法及依从性

Patients opinion and adherence to antimalarials in lupus erythematosus and rheumatoid arthritis treatment.

作者信息

Cabral Renata Tavares de Souza, Klumb Evandro Mendes, Carneiro Sueli

机构信息

Ophthalmology Service, Retina and Vitreo Departamento, Pedro Ernesto University Hospital (HUPE), State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.

Rheumatology, FCM/UERJ, Rio de Janeiro, Brazil.

出版信息

J Dermatolog Treat. 2020 May;31(3):264-269. doi: 10.1080/09546634.2019.1595504. Epub 2019 Apr 2.

Abstract

To obtain the opinion of patients with rheumatoid arthritis or lupus erythematosus about the use of antimalarials through questionnaires and to evaluate their adherence to medication. A cross-sectional study of patients treated with antimalarial medication for a period equal to or longer than 1 year attended between November 2012 and October 2014. A structured questionnaire with 12 questions was filled out. Among 300 patients examined, 92% (275) used medication regularly. Hydroxychloroquine was used by 55% (166) of patients, chloroquine by 25% (75), and 20% (59) reported using both medications at different moments. Most of the patients (221 or 74%) were using medication seven days a week and had taken it for a period longer than 5 years; 61% (182) considered the treatment good and said, 21% (63) said, 'It is good, but I'm afraid of taking it'. Most of the patients (70% or 211) did not report any adverse symptoms. Their main claim was related to blurred vision, which was solved by a refraction examination. Fear has been a factor that makes adherence to treatment difficult. Making patients aware of the importance of the treatment is strongly relevant because antimalarials are well tolerated.

摘要

通过问卷调查获取类风湿性关节炎或红斑狼疮患者对抗疟药使用的看法,并评估他们对药物治疗的依从性。对2012年11月至2014年10月期间接受抗疟药治疗达1年及以上的患者进行横断面研究。填写一份包含12个问题的结构化问卷。在300名接受检查的患者中,92%(275名)患者规律用药。55%(166名)患者使用羟氯喹,25%(75名)使用氯喹,20%(59名)报告在不同时期使用过这两种药物。大多数患者(221名或74%)每周七天都在用药,且用药时间超过5年;61%(182名)认为治疗效果良好,21%(63名)表示“效果不错,但我害怕服用”。大多数患者(70%或211名)未报告任何不良反应。他们主要的诉求与视力模糊有关,通过验光检查得以解决。恐惧一直是导致治疗依从性差的一个因素。让患者意识到治疗的重要性非常关键,因为抗疟药耐受性良好。

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