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Immune responses during human Schistosomiasis mansoni. Evidence for antiidiotypic T lymphocyte responsiveness.

作者信息

Lima M S, Gazzinelli G, Nascimento E, Parra J C, Montesano M A, Colley D G

出版信息

J Clin Invest. 1986 Oct;78(4):983-8. doi: 10.1172/JCI112689.

DOI:10.1172/JCI112689
PMID:3093535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC423737/
Abstract

We present a method for the examination of antiidiotypic cell-mediated reactivity during chronic human infections. Pooled and individual sera from patients with schistosomiasis mansoni were purified on immunoaffinity columns of schistosomal egg antigens (SEA). The eluates contained anti-SEA antibodies, but not SEA. These antibody preparations, and their F(ab)2 fragments, stimulated dose-dependent proliferation of peripheral blood mononuclear cells (PBMN) and T lymphocytes from some, but not all active or former schistosomiasis mansoni patients, and could do so autologously. Stimulation required presentation by plastic-adherent cells. The eluates did not stimulate PBMN from persons who had never had schistosomiasis. Affinity-purified anti-SEA antibodies from former patients (cured for greater than 10 yr) did not stimulate PBMN from patients with active infections. Reabsorption on SEA columns removed stimulatory activity from the eluates. We propose that multiclonal, SEA-related idiotypes expressed by some anti-SEA antibodies stimulate proliferation of T lymphocytes that express antiidiotypic specificities.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930d/423737/1ad82dd785e4/jcinvest00109-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930d/423737/1ad82dd785e4/jcinvest00109-0136-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/930d/423737/1ad82dd785e4/jcinvest00109-0136-a.jpg

相似文献

1
Immune responses during human Schistosomiasis mansoni. Evidence for antiidiotypic T lymphocyte responsiveness.
J Clin Invest. 1986 Oct;78(4):983-8. doi: 10.1172/JCI112689.
2
Immune responses during human schistosomiasis mansoni. XV. Anti-idiotypic T cells can recognize and respond to anti-SEA idiotypes directly.曼氏血吸虫病患者的免疫反应。十五、抗独特型T细胞可直接识别并对抗SEA独特型作出反应。
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4
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引用本文的文献

1
Immunology of human schistosomiasis.人类血吸虫病的免疫学
Parasite Immunol. 2014 Aug;36(8):347-57. doi: 10.1111/pim.12087.
2
Neonatal idiotypic exposure alters subsequent cytokine, pathology, and survival patterns in experimental Schistosoma mansoni infections.新生儿独特型暴露会改变实验性曼氏血吸虫感染中后续的细胞因子、病理及生存模式。
J Exp Med. 1999 Feb 15;189(4):637-45. doi: 10.1084/jem.189.4.637.
3
Two distinct pathological syndromes in male CBA/J inbred mice with chronic Schistosoma mansoni infections.感染曼氏血吸虫的雄性CBA/J近交系小鼠中存在两种不同的病理综合征。

本文引用的文献

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Monoclonal idiotope vaccine against Streptococcus pneumoniae infection.抗肺炎链球菌感染的单克隆独特型表位疫苗。
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A rapid method for separating functionally intact human T lymphocytes with monoclonal antibodies.一种用单克隆抗体分离功能完整的人T淋巴细胞的快速方法。
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Neonatal administration of idiotype or antiidiotype primes for protection against Escherichia coli K13 infection in mice.新生小鼠接种独特型或抗独特型可引发对大肠杆菌K13感染的保护作用。
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