Department of Community and Public Health, Faculty of Health Sciences, Busitema University, P.O. Box, 1460, Mbale, Uganda.
Department of Biochemistry and Molecular Biology, Faculty of Health Sciences, Busitema University, P.O. Box, 1460, Mbale, Uganda.
BMC Infect Dis. 2019 Apr 1;19(1):295. doi: 10.1186/s12879-019-3939-x.
The prevalence of Plasmodium falciparum and Intestinal Parasitic Infections (IPIs) - with the corresponding pathogenesis among children remain uncertain. This study aimed at determining the prevalence and the outcomes (including anaemia) of the respective infections and co-infections. Anaemia is a condition in which the number of red blood cells transporting oxygen to the various body parts is not sufficient to meet the needs of the body.
This was a cross sectional study conducted among 476-refugee camp school children. Kato-Katz technique was used to screen stool samples for intestinal parasites. Microscopy was used for malaria testing while the portable Haemoglobin (Hb) calorimeter was used to measure haemoglobin concentration.
The overall prevalence of the mixed infections was 63.03%. Plasmodium falciparum was most prevalent of the single infections 262(55.04%) followed by Taenia spp. 14 (2.9%), Schistosoma mansoni 12(2.5%), Giardia lamblia 7 (2.9%), Trichuris trichiura 2(0.4%), Hookworm 2(0.4%) and Strongyloides stercoralis 1(0.2%). The odds of developing simple or uncomplicated malaria infection or anaemia was 14 times higher in individuals with dual co-infection with Plasmodium falciparum + Taenia sp. compared to single parasitic infection (Odds = 14.13, P = 0.019). Co-infection with Plasmodium falciparum + Taenia spp, was a strong predictor of Malaria and anaemia.
This study shows that Plasmodium falciparum and Taenia spp. co-infections is a stronger predictor of malaria and anaemia. The prevalence of malaria and anaemia remains higher than the other regions in Uganda outside restricted settlements. The findings of this study underline the need for pragmatic intervention programmes to reduce burden of the co-infections in the study area and similar settlements.
疟原虫和肠道寄生虫感染（IPIs）的流行率——以及儿童的相应发病机制仍不确定。本研究旨在确定各自感染和合并感染的流行率和结果（包括贫血）。贫血是一种向身体各部位输送氧气的红细胞数量不足以满足身体需求的情况。
这是一项在 476 名难民营学校儿童中进行的横断面研究。加藤厚涂片技术用于筛查粪便样本中的肠道寄生虫。显微镜用于疟疾检测，而便携式血红蛋白（Hb）热量计用于测量血红蛋白浓度。
混合感染的总流行率为 63.03%。单一感染中最常见的是恶性疟原虫 262 例（55.04%），其次是带绦虫 14 例（2.9%）、曼氏血吸虫 12 例（2.5%）、蓝氏贾第鞭毛虫 7 例（2.9%）、鞭虫 2 例（0.4%）、钩虫 2 例（0.4%）和粪类圆线虫 1 例（0.2%）。与单一寄生虫感染相比，双重合并感染疟原虫+带绦虫的个体发生单纯或不复杂疟疾感染或贫血的几率高 14 倍（优势比=14.13，P=0.019）。疟原虫+带绦虫的合并感染是疟疾和贫血的强烈预测因素。
本研究表明，疟原虫和带绦虫的合并感染是疟疾和贫血的更强预测因素。疟疾和贫血的流行率仍然高于乌干达境外限制定居点的其他地区。本研究结果强调需要实施务实的干预方案，以减少研究区域和类似定居点合并感染的负担。
