University of Saskatchewan, School of Public Health, 104 Clinic Place, Saskatoon, SK, S7N 2Z4, Canada.
University of Saskatchewan, School of Public Health, 104 Clinic Place, Saskatoon, SK, S7N 2Z4, Canada.
Complement Ther Med. 2019 Apr;43:188-195. doi: 10.1016/j.ctim.2019.02.010. Epub 2019 Feb 10.
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the myelinated axons of the central nervous system causing neurological deterioration. People living with MS have a poor quality of life (QOL) because of the symptoms caused by the disease and there are various types of treatments to manage the symptoms aside from medication.
This meta-analysis examines the effect of exercise, yoga and physiotherapy on the physical, mental and social QOL among individuals living with MS.
A systematic review with meta-analysis was conducted using PubMed, Medline, and Scopus from 1990 to 2017. The standard mean difference scores were computed in each study for the domains of physical, mental and social functioning.
Eighteen studies met the inclusion criteria for this meta-analysis. Aerobic exercise was effective in improving satisfaction with physical functioning,d = 0.35 (95% CI = 0.08 to 0.62), mental functioning d = 0.42 (95% CI = 0.11 to 0.72), and social functioning d = 0.42 (95% CI = 0.15 to 0.69). Physiotherapy was also found to be effective for physical functioning d = 0.50 (95% CI 0.19 to 0.80), mental functioning d = 0.44 (95% CI 0.14 to 0.75) and social functioning d = 0.60 (95% CI 0.21 to 0.90). However yoga and combination of exercises did not have a significant effect on any of the QOL domains.
These findings suggest that aerobic exercise and physiotherapy improves the satisfaction of MS patients with their physical, mental and social functioning and may be included as normal practice in the treatment of MS.
多发性硬化症（MS）是一种影响中枢神经系统髓鞘轴突的慢性自身免疫性疾病，会导致神经功能恶化。由于疾病引起的症状，MS 患者的生活质量（QOL）较差，除了药物治疗外，还有各种类型的治疗方法来控制症状。
本荟萃分析研究了运动、瑜伽和物理疗法对 MS 患者身体、心理和社会 QOL 的影响。
对 1990 年至 2017 年期间的 PubMed、Medline 和 Scopus 进行了系统评价和荟萃分析。在每个研究中，针对身体、心理和社会功能领域，计算了标准均数差值分数。
有 18 项研究符合本荟萃分析的纳入标准。有氧运动在改善身体功能的满意度方面是有效的，d=0.35（95%CI=0.08 至 0.62），心理功能 d=0.42（95%CI=0.11 至 0.72），社会功能 d=0.42（95%CI=0.15 至 0.69）。物理疗法也被发现对身体功能 d=0.50（95%CI 0.19 至 0.80）、心理功能 d=0.44（95%CI 0.14 至 0.75）和社会功能 d=0.60（95%CI 0.21 至 0.90）有效。然而，瑜伽和运动的组合对任何 QOL 领域都没有显著影响。
这些发现表明，有氧运动和物理疗法可以提高 MS 患者对身体、心理和社会功能的满意度，并且可以作为 MS 治疗的常规实践。
