Department of Radiology, Division of Interventional Radiology, Hospital of the University of Pennsylvania, Perelman School of Medicine, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104.
Cook Research Incorporated, West Lafayette, Indiana.
J Vasc Interv Radiol. 2019 Jun;30(6):949-955. doi: 10.1016/j.jvir.2018.10.004. Epub 2019 Mar 29.
To determine whether nylon fibers improve the performance of platinum embolization coils in porcine arteries.
Platinum 0.035" embolization coils, both with and without nylon fibers, were used to embolize a total of 24 hindlimb arteries in 6 swine: 12 with fibered coils and 12 with non-fibered coils. Apart from fibers, the coils were identical. Immediate and late results were studied, including number of coils needed to achieve vessel occlusion and durability of occlusion at 1 and 3 months. Arteriographic as well as histopathologic analysis were performed.
A mean of 3.2 (range, 2-4) non-fibered coils was required to achieve occlusion, whereas a mean of 1.3 (range, 1-2) fibered coils achieved occlusion in similarly sized arteries (2.3-3.2-mm diameter, P < .001). The mean percent cross-sectional area occupied by thrombus was greater in arteries with fibered coils than with non-fibered coils at 1 month (63% ± 6% and 48% ± 15%, respectively, P = .03) but not at 3 months (61% ± 6% and 49% ± 15%, respectively, P = .06). Some recanalization was observed at follow-up and did not differ between groups at 1 month (P = .07) or 3 months (P = .22).
Nylon fibers allow significantly fewer embolization coils to achieve acute occlusion of arteries compared to bare metal coils. Both fibered and non-fibered coils showed recanalization at follow-up.
确定尼龙纤维是否能提高铂微弹簧圈在猪动脉中的栓塞性能。
使用带有和不带有尼龙纤维的 0.035 英寸铂微弹簧圈栓塞总共 6 头猪的 24 条后肢动脉：12 条带有纤维圈，12 条带有非纤维圈。除纤维外，线圈完全相同。研究了即刻和晚期结果，包括达到血管闭塞所需的线圈数量以及 1 个月和 3 个月时闭塞的耐久性。进行了血管造影和组织病理学分析。
在同样大小的动脉（直径 2-3.2 毫米）中，需要 3.2（范围 2-4）个非纤维圈来实现闭塞，而 1.3（范围 1-2）个纤维圈就可以实现闭塞（P<.001）。在 1 个月时，带有纤维圈的动脉中血栓的横截面积百分比大于不带纤维圈的动脉（分别为 63%±6%和 48%±15%，P=.03），但在 3 个月时则无差异（分别为 61%±6%和 49%±15%，P=.06）。在随访中观察到一些再通，并且在 1 个月（P=.07）或 3 个月（P=.22）时两组之间没有差异。
与裸金属线圈相比，尼龙纤维可显著减少用于实现动脉急性闭塞的栓塞线圈数量。纤维圈和非纤维圈在随访中均有再通。
