Oda H, Matsuoka S, Yoshida A
J Nutr. 1986 Sep;116(9):1660-6. doi: 10.1093/jn/116.9.1660.
Liver weight, liver and urinary ascorbic acid levels and serum cholesterol concentration were higher in rats fed polychlorinated biphenyls (PCB) than in controls. The influences of methionine, cystine and potassium sulfate on these metabolic responses were studied. Methionine or equivalent moles of cystine or potassium sulfate were added to a basal diet containing 10% soy protein isolate. The basal diet contained 0.3% of total sulfur-containing amino acids (S-AAs). When methionine was added to the basal diet, maximum gain in body weight was obtained with 0.5% of dietary S-AAs, while the highest values in serum cholesterol and urinary ascorbic acid were obtained with 0.8% of dietary S-AAs in rats fed PCB. Dietary addition of cystine had little effect on body weight gain. Nevertheless, in rat fed PCB, urinary ascorbic acid and serum cholesterol were significantly higher in rats fed the cystine-supplemented diet than in those fed the unsupplemented diet. Addition of potassium sulfate had no effect on body weight gain, urinary ascorbic acid or serum cholesterol. These results suggest that more S-AAs are required for the highest metabolic response to PCB than for maximum growth, and the higher requirement for S-AAs cannot be replaced by inorganic sulfate.
喂食多氯联苯（PCB）的大鼠肝脏重量、肝脏和尿液中的抗坏血酸水平以及血清胆固醇浓度均高于对照组。研究了蛋氨酸、胱氨酸和硫酸钾对这些代谢反应的影响。将蛋氨酸或等量摩尔的胱氨酸或硫酸钾添加到含有10%大豆分离蛋白的基础日粮中。基础日粮含有0.3%的总含硫氨基酸（S-AAs）。当向基础日粮中添加蛋氨酸时，日粮S-AAs含量为0.5%时体重增加最大，而在喂食PCB的大鼠中，日粮S-AAs含量为0.8%时血清胆固醇和尿液抗坏血酸值最高。日粮中添加胱氨酸对体重增加影响不大。然而，在喂食PCB的大鼠中，喂食补充胱氨酸日粮的大鼠尿液抗坏血酸和血清胆固醇显著高于未补充日粮的大鼠。添加硫酸钾对体重增加、尿液抗坏血酸或血清胆固醇没有影响。这些结果表明，与最大生长相比，对PCB的最高代谢反应需要更多的S-AAs，且S-AAs的较高需求不能被无机硫酸盐替代。
