Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China,
Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China,
Clin Interv Aging. 2019 Mar 14;14:565-570. doi: 10.2147/CIA.S190984. eCollection 2019.
Chronic cerebral circulation insufficiency (CCCI) is viewed as an alarming state induced by long-term reduction in cerebral perfusion, which is associated with neurological deficits and high risk of stroke occurrence or recurrence. CCCI accounts for a large proportion of both outpatients and inpatients with cerebrovascular diseases, while management of CCCI remains a formidable challenge to clinicians. Normobaric oxygen (NBO) is an adjuvant hyperoxygenation intervention supplied with one atmosphere pressure (1 ATA =101.325 kPa). A plethora of studies have demonstrated the efficacy of NBO on the penumbra in acute stroke. NBO has been shown to increase the oxygen pressure, raise the intracranial blood flow, protect blood-brain barrier and enhance neuroprotective effects. As similar underlying mechanisms are shared by the penumbra in stroke and the ischemic-hypoxic brain tissues in CCCI, we speculate that NBO may serve as a promising therapeutic strategy for attenuating short-term symptoms or improving long-term clinical outcomes among patients with CCCI. Due to the scant research exploring the efficacy and safety of NBO for treating CCCI so far, both experimental and clinical studies are warranted to verify our hypothesis in the future.
慢性脑循环不全（CCCI）被认为是由长期脑灌注减少引起的一种危急状态，与神经功能缺损和中风发生或复发的高风险相关。CCCI 占脑血管病门诊和住院患者的很大比例，而 CCCI 的治疗仍然是临床医生面临的巨大挑战。常压氧（NBO）是一种在 1 个大气压（1ATA=101.325kPa）下提供的辅助高氧干预措施。大量研究表明 NBO 对急性中风的半影区有效。NBO 已被证明可以增加氧压、提高颅内血流量、保护血脑屏障并增强神经保护作用。由于中风半影区和 CCCI 中的缺血缺氧脑组织具有相似的潜在机制，我们推测 NBO 可能成为减轻 CCCI 患者短期症状或改善长期临床结局的有前途的治疗策略。由于目前为止很少有研究探讨 NBO 治疗 CCCI 的疗效和安全性，因此需要进行实验和临床研究来验证我们的假设。
