骨骼肌中的周细胞。

Pericytes in Skeletal Muscle.

机构信息

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, USA.

出版信息

Adv Exp Med Biol. 2019;1122:59-72. doi: 10.1007/978-3-030-11093-2_4.

Abstract

Skeletal muscle regeneration is a highly orchestrated process and involves the activation of many cellular and molecular pathways. Although satellite cells (SCs) are the major cell type responsible for muscle regeneration, pericytes show remarkable myogenic potential and various advantages as cell therapy in muscular disorders. This chapter first introduces the structure, marker expression, origin, and category of pericytes. Next, we discuss their functions in muscular dystrophy and/or muscle injuries, focusing on their myogenic, adipogenic, fibrogenic, chondrogenic, and osteogenic activities. Understanding this knowledge will promote the development of innovative cell therapies for muscle disorders, including muscular dystrophy.

摘要

骨骼肌再生是一个高度协调的过程，涉及许多细胞和分子途径的激活。虽然卫星细胞（SCs）是负责肌肉再生的主要细胞类型，但周细胞具有显著的成肌潜能和作为肌肉疾病细胞治疗的各种优势。本章首先介绍周细胞的结构、标志物表达、起源和分类。接下来，我们讨论它们在肌肉疾病和/或肌肉损伤中的功能，重点关注它们的成肌、成脂、成纤维、成软骨和成骨活性。了解这些知识将促进肌肉疾病的创新细胞治疗的发展，包括肌肉营养不良症。