Zhang Jian, Léonard Didier, Mazurczyk Radoslaw, Yeromonahos Christelle, Monnier Virginie, Géhin Thomas, Monfray Stéphane, Chevolot Yann, Cloarec Jean-Pierre
Université de Lyon, Institut des Nanotechnologies de Lyon (INL) UMR CNRS 5270, Ecole Centrale de Lyon, 36 Avenue Guy de Collongue, 69134 Ecully cedex, France.
Nanotechnology. 2019 Aug 9;30(32):325601. doi: 10.1088/1361-6528/ab1556. Epub 2019 Apr 2.
The evolution of nanobiosensors stresses the need for multi-material nanopatterned surfaces to enhance sensing performances. Titanium tungsten (TiW) has been mastered and routinely implemented in nanoelectronic devices, in a reproducible way and at industrial production scales. Such a material may be envisioned for use in (bio)chemical nanoelectronic sensors, but the surface functionalization of such material has yet to be studied. In the present article, the orthogonal chemical functionalization of patterned Au on TiW substrates has been explored for the first time. Surface functionalizations were assessed by x-ray photoelectron spectroscopy, polarization modulation infrared reflection-absorption spectroscopy and time-of-flight secondary ion mass spectrometry imaging. Au/TiW patterned substrates were functionalized with mercapto-undecamine. Thanks to the orthogonality of thiol/Au versus phosphonic acid/TiW reactions, only the Au features were modified leading to the amine derivatized surface. This allowed for the localizing of carboxy-functionalized nanoparticles by electrostatic interaction on Au with a selectivity above 10 when compared to TiW.
纳米生物传感器的发展凸显了对多材料纳米图案化表面的需求，以提高传感性能。钛钨（TiW）已被掌握并常规应用于纳米电子器件中，且能以可重复的方式在工业生产规模上实现。这种材料有望用于（生物）化学纳米电子传感器，但这种材料的表面功能化尚未得到研究。在本文中，首次探索了在TiW衬底上对图案化金进行正交化学功能化。通过X射线光电子能谱、偏振调制红外反射吸收光谱和飞行时间二次离子质谱成像对表面功能化进行了评估。用巯基十一胺对Au/TiW图案化衬底进行功能化。由于硫醇/金与膦酸/TiW反应的正交性，只有金特征被修饰，从而得到胺衍生化表面。与TiW相比，这使得通过静电相互作用在金上定位羧基功能化纳米颗粒的选择性高于10。
