Gorczynski R M, Cunningham A J
Eur J Immunol. 1978 Oct;8(10):753-5. doi: 10.1002/eji.1830081015.
The in vitro secondary anti-hapten response to trinitrophenylated keyhole limpet hemocyanin (TNP-KLH) has been investigated using B and T cells from the same or a pool of identically primed syngeneic individuals. The optimum antibody response obtained from B cells of any given animal was seen when the same individual's T cells were used as a helper cell source. This individual preference was lost if secondary challenge in culture was made with TNP on a heterologous carrier, with the helper cells obtained from suitably primed individuals or a pool thereof. These data are interpreted in terms of a network theory for the regulation of immune responses under physiological conditions.
利用来自同一或一组经相同免疫的同基因个体的B细胞和T细胞，研究了对三硝基苯基化的钥孔戚血蓝蛋白（TNP-KLH）的体外继发性抗半抗原反应。当使用同一个体的T细胞作为辅助细胞来源时，可从任何给定动物的B细胞中获得最佳抗体反应。如果在培养中用异源载体上的TNP进行二次攻击，并从适当免疫的个体或其混合群体中获得辅助细胞，这种个体偏好就会消失。这些数据根据生理条件下免疫反应调节的网络理论进行解释。
