T淋巴细胞依赖性B淋巴细胞对抗原的增殖反应。I. B淋巴细胞增殖刺激的遗传限制
T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation.
作者信息
Tse H Y, Mond J J, Paul W E
出版信息
J Exp Med. 1981 Apr 1;153(4):871-82. doi: 10.1084/jem.153.4.871.
Abstract
For the purpose of examining more closely the interaction between T and B lymphocytes, we have developed an in vitro T lymphocyte-dependent B lymphocyte proliferation assay. Proliferation of B lymphocytes in response to antigen was found to depend on the presence of primed T lymphocytes; the B lymphocytes could be derived from nonprimed animals. It appears that these B cells were nonspecifically recruited to proliferate. This nonspecific recruitment, however, was found to be Ir-gene restricted in that B lymphocytes from B10.S mice, which are genetic nonresponders to the polymer Glu60-Ala30-Tyr10 (GAT), could not be stimulated by GAT-primed (responder X nonresponder) F1 T cells. The apparent lack of antigen specificity in the face of Ir gene-restricted T-B interaction may have important implications in our understanding of the recognition unit(s) on T lymphocytes.
摘要
为了更深入地研究T淋巴细胞与B淋巴细胞之间的相互作用，我们开发了一种体外T淋巴细胞依赖性B淋巴细胞增殖试验。发现B淋巴细胞对抗原的增殖反应依赖于致敏T淋巴细胞的存在；B淋巴细胞可以来自未致敏的动物。似乎这些B细胞是被非特异性募集来增殖的。然而，发现这种非特异性募集受Ir基因限制，因为来自B10.S小鼠的B淋巴细胞，它们对聚合物Glu60-Ala30-Tyr10（GAT）是遗传无反应者，不能被GAT致敏的（反应者×无反应者）F1 T细胞刺激。面对Ir基因限制的T-B相互作用时明显缺乏抗原特异性，这可能对我们理解T淋巴细胞上的识别单位具有重要意义。
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本文引用的文献
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T-cell-dependent B-cell stimulation is H-2 restricted and antigen dependent only at the resting B-cell level.T细胞依赖性B细胞刺激是H-2限制性的，并且仅在静止B细胞水平上依赖抗原。
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The role of H-2-linked genes in helper T cell function. VII. Expression of I region and immune response genes by B cells in bystander help assays.H-2 连锁基因在辅助性 T 细胞功能中的作用。VII. 在旁观者辅助测定中 B 细胞对 I 区基因和免疫反应基因的表达。
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Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.豚鼠T淋巴细胞抗原识别中巨噬细胞的作用。I. 对组织相容性巨噬细胞和淋巴细胞的需求。
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Proliferation by bone marrow-derived lymphocytes in response to antigenic stimulation in vitro.骨髓来源的淋巴细胞在体外对抗抗原刺激的增殖反应。
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Genetic control of immune responses in vitro. I. Development of primary and secondary plaque-forming cell responses to the random terpolymer 1-glutamic acid 60-1-alanine30-1-tyrosine10 (GAT) by mouse spleen cells in vitro.体外免疫反应的遗传控制。I. 小鼠脾细胞在体外对随机三元共聚物1-谷氨酸60-1-丙氨酸30-1-酪氨酸10（GAT）的初次和二次噬斑形成细胞反应的发展。
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Cell interactions between histoincompatible T and B lymphocytes. VII. Cooperative responses between lymphocytes are controlled by genes in the I region of the H-2 complex.组织相容性不相容的T淋巴细胞和B淋巴细胞之间的细胞相互作用。VII.淋巴细胞之间的协同反应受H-2复合体I区基因的控制。
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The induction and regulation of guinea pig B-lymphocyte proliferation in vitro.豚鼠B淋巴细胞体外增殖的诱导与调控
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