Wang Jing, Niu Jian-Fei, Li Guan-Hui, Zhao Xiao-Feng
Graduate School of Tianjin University of TCM, Tianjin 300193, China.
The First Teaching Hospital of Tianjin University of TCM, Tianjin 300193.
Zhongguo Zhen Jiu. 2019 Feb 12;39(2):224-8. doi: 10.13703/j.0255-2930.2019.02.031.
The relevant literature of pathogenesis of essential hypertension (EH) and the clinical efficacy of acupuncture treatment of EH was retrieved from January 1, 1999 to February 28, 2018 in the CNKI and PubMed databases, and aimed to summarize and explore the mechanism of antihypertensive by acupuncture.It has been found that acupuncture exerts antihypertensive effect by coordinating multi-system, multi-target, multi-layer adjustment mechanism, such as acupuncture inhibiting of central and peripheral sympathetic nerve activity, rejusting immune system and expression of inflammatory response factors, regulating the balance of renin-angiotensin-aldosterone system (RAAS), improving vascular structure and function, the anti-oxidative stress and promoting autophagy.
检索1999年1月1日至2018年2月28日期间中国知网（CNKI）和美国国立医学图书馆生物医学期刊数据库（PubMed）中关于原发性高血压（EH）发病机制及针刺治疗EH临床疗效的相关文献，旨在总结并探讨针刺降压机制。研究发现，针刺通过协调多系统、多靶点、多层次的调节机制发挥降压作用，如针刺抑制中枢及外周交感神经活动、调节免疫系统及炎症反应因子表达、调节肾素-血管紧张素-醛固酮系统（RAAS）平衡、改善血管结构和功能、抗氧化应激及促进自噬等。
