Yu Zheng, Wu Qiao-Feng, Liang Fan-Rong
Zhen Ci Yan Jiu. 2014 Aug;39(4):333-6.
Essential hypertension (EH) is a very common clinical disorder affecting the patient's health. Accumulating evidence indicates that immunological factors play an important role in the pathogenesis of hypertension. In the present paper, the authors introduce 1) progress of researches on the pathogenesis of hypertension from cellular immune and body fluid immune (multiple immuno-humoral factors); 2) effects of acupuncture intervention on natural killer cell activity, exercise-induced immunosuppression, circulating inflammatory factor levels and balance of cytokines; 3) blood-pressure reduction effect of acupuncture intervention by lowering circulating TNF-alpha, IL-6, matrix metalloproteinases-9, angiotensin convertase and endothelin levels, and up-regulating serum opioid peptide content, etc. to decrease inflammatory injury of the cardiovascular system. Many researches have demonstrated that acupuncture may have a positive role in improving EH in clinical practice, which may be associated with its regulative effect on immune system, but its mechanism has not been fully elucidated.
原发性高血压（EH）是一种非常常见的影响患者健康的临床疾病。越来越多的证据表明，免疫因素在高血压发病机制中起重要作用。在本文中，作者介绍了：1）从细胞免疫和体液免疫（多种免疫体液因子）方面对高血压发病机制的研究进展；2）针刺干预对自然杀伤细胞活性、运动性免疫抑制、循环炎症因子水平及细胞因子平衡的影响；3）针刺干预通过降低循环肿瘤坏死因子-α、白细胞介素-6、基质金属蛋白酶-9、血管紧张素转换酶和内皮素水平，上调血清阿片肽含量等降低血压，以减轻心血管系统的炎症损伤。许多研究表明，针刺在临床实践中对改善原发性高血压可能具有积极作用，这可能与其对免疫系统的调节作用有关，但其机制尚未完全阐明。
