Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand.
Structure. 2019 Apr 2;27(4):564-565. doi: 10.1016/j.str.2019.03.011.
Deubiquitinases (DUBs) are important regulators of cellular function and selective inhibitors are required to reveal their biological role and therapeutic potential. In this issue of Structure, Teyra et al. (2019) report the development of DUB USP15 inhibitors that provide a starting point for the analysis of USP15 function.
去泛素化酶（DUBs）是细胞功能的重要调节剂，需要选择性抑制剂来揭示其生物学功能和治疗潜力。在本期的《结构》杂志中，Teyra 等人（2019 年）报道了 DUB USP15 抑制剂的开发，为分析 USP15 功能提供了一个起点。
