肠道 T 细胞通过摄取 GLP-1 来调节心脏代谢疾病。

Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease.

机构信息

Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2S2, Canada.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.

出版信息

Cell Metab. 2019 Apr 2;29(4):787-789. doi: 10.1016/j.cmet.2019.03.002.

DOI:10.1016/j.cmet.2019.03.002

PMID:30943389

Abstract

Glucagon-like peptide-1 (GLP-1) is an enteroendocrine hormone that controls insulin secretion, intestinal function, and food intake. Recently in Nature, He et al. (2019) reported that gut intraepithelial T cells regulate GLP-1 bioavailability by capturing it on GLP-1 receptors and impacting L-cell numbers. This study delineates a novel endocrine-immune axis through which intestinal immune cells regulate whole-body metabolism.

摘要

胰高血糖素样肽-1（GLP-1）是一种肠内分泌激素，它可以控制胰岛素分泌、肠道功能和食物摄入。最近，He 等人在《自然》杂志上报道称，肠道上皮内 T 细胞通过捕获 GLP-1 受体上的 GLP-1 并影响 L 细胞数量来调节 GLP-1 的生物利用度。这项研究描绘了一条新的内分泌-免疫轴，通过这条轴，肠道免疫细胞可以调节全身代谢。