Department of Immunology, University of Toronto, Toronto, ON, Canada.
Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON, Canada.
Nat Commun. 2021 May 10;12(1):2598. doi: 10.1038/s41467-021-22727-7.
The intestinal immune system is an important modulator of glucose homeostasis and obesity-associated insulin resistance. Dietary factors, the intestinal microbiota and their metabolites shape intestinal immunity during obesity. The intestinal immune system in turn affects processes such as intestinal permeability, immune cell trafficking, and intestinal hormone availability, impacting systemic insulin resistance. Understanding these pathways might identify mechanisms underlying treatments for insulin resistance, such as metformin and bariatric surgery, or aid in developing new therapies and vaccination approaches. Here, we highlight evolving concepts centered on intestinal immunity, diet, and the microbiota to provide a working model of obesity-related metabolic disease.
肠道免疫系统是调节葡萄糖稳态和肥胖相关胰岛素抵抗的重要因素。饮食因素、肠道微生物群及其代谢产物在肥胖期间塑造肠道免疫。反过来，肠道免疫系统会影响肠道通透性、免疫细胞迁移和肠道激素可用性等过程，从而影响全身胰岛素抵抗。了解这些途径可能有助于确定治疗胰岛素抵抗的机制，如二甲双胍和减肥手术，或有助于开发新的治疗方法和疫苗接种方法。在这里，我们重点介绍以肠道免疫、饮食和微生物群为中心的不断发展的概念，为肥胖相关代谢疾病提供一个工作模型。
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