台湾南部病毒性前葡萄膜炎的流行病学及临床特征——聚合酶链反应诊断法
Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction.
作者信息
Hsiao Yu-Ting, Kuo Ming-Tse, Chiang Wei-Yu, Chao Tsai-Ling, Kuo Hsi-Kung
机构信息
Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist, Kaohsiung, 833, Taiwan.
出版信息
BMC Ophthalmol. 2019 Apr 3;19(1):87. doi: 10.1186/s12886-019-1093-2.
BACKGROUND
To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan.
METHODS
A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Their records were reviewed for demographic data, ocular findings, and laboratory results.
RESULTS
In the aqueous samples obtained from 102 eligible eyes, 42 eyes were herpesviridae-positive, which included 9 with herpes simplex virus (8.8%), 5 with varicella-zoster virus (4.9%), 27 with cytomegalovirus (26.5%), and 1 with Epstein-Barr virus (1%). Herpesviridae-positive patients were more likely to be male, and have glaucoma. Glaucoma and pseudophakic eyes were significantly associated with CMV-positive eyes.
CONCLUSION
PCR analysis of the anterior chamber fluid is important for the confirmation of the diagnosis of viral anterior uveitis. Cytomegalovirus anterior uveitis is not uncommon in patients in southern Taiwan, and it may follow an uneventful cataract extraction in immunocompetent patients.
背景
报告台湾南部地区患者病毒性前葡萄膜炎的流行病学及临床特征。
方法
一项回顾性病例系列研究。对2007年1月1日至2018年1月31日期间在高雄长庚纪念医院就诊的眼压升高或角膜水肿的HLA - B27阴性前葡萄膜炎患者，采集房水进行聚合酶链反应分析。回顾其记录以获取人口统计学数据、眼部检查结果及实验室检查结果。
结果
在从102只符合条件的眼睛获取的房水样本中，42只眼睛疱疹病毒科检测呈阳性，其中9只感染单纯疱疹病毒（8.8%），5只感染水痘 - 带状疱疹病毒（4.9%），27只感染巨细胞病毒（26.5%），1只感染爱泼斯坦 - 巴尔病毒（1%）。疱疹病毒科检测呈阳性的患者更可能为男性，且患有青光眼。青光眼和人工晶状体眼与巨细胞病毒阳性眼显著相关。
结论
前房液的PCR分析对于确诊病毒性前葡萄膜炎很重要。巨细胞病毒性前葡萄膜炎在台湾南部地区患者中并不少见，且在免疫功能正常的患者中，白内障摘除术后可能无异常情况发生。
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