1Department of Endocrinology,Diabetes and Metabolism,Christian Medical College & Hospital,Vellore,Tamil Nadu,India.
3Department of General Practice,Faculty of Medicine,Dentistry and Health Science,University of Melbourne,Australia.
J Biosoc Sci. 2019 Jul;51(4):619-621. doi: 10.1017/S0021932019000166. Epub 2019 Apr 4.
High body fat in apparently lean individuals is a commonly described phenotype in individuals of Asian descent, but very limited consolidated scientific literature is available on this topic. This phenotype is known as 'normal-weight obesity' and may explain the large disparity between the prevalence of obesity (as measured by BMI) and diabetes that occurs in these individuals. Routine use of obesity indicators that best predict body fat content would help to identify these individuals in clinical practice. In this debate, we would like to highlight that even though fat and BMI have a good correlation, as suggested by Kryst et al. (2019), clinicians, public health researchers and policymakers should consider the use of these indicators in conjunction with each other rather than individually. Future research is needed on pathogenic mechanisms, diagnostic modalities and therapeutic options in these individuals which will help to further characterize and manage these patients appropriately.
在亚洲人群中，体型看似偏瘦但体脂率却偏高的人群较为常见，但目前针对这一表型的相关科学文献非常有限。这种表型被称为“正常体重肥胖”，可能正是造成这些人群中肥胖症（以 BMI 衡量）和糖尿病患病率差异巨大的原因。在临床实践中，若能常规使用最能预测体脂含量的肥胖指标，将有助于识别这类人群。在本次辩论中，我们想强调的是，尽管 Kryst 等人（2019 年）的研究表明脂肪和 BMI 之间具有很好的相关性，但临床医生、公共卫生研究人员和政策制定者在使用这些指标时，应考虑将它们结合起来，而不是单独使用。未来还需要对这些人群的发病机制、诊断方法和治疗选择进行研究，以进一步对这些患者进行适当的特征描述和管理。
