新型喹诺酮类药物CI - 934对粪肠球菌的杀菌活性速率与阿莫西林的比较。
Rate of bactericidal activity for Streptococcus faecalis of a new quinolone, CI-934, compared with that of amoxicillin.
作者信息
Yourassowsky E, Van der Linden M P, Lismont M J, Crokaert F, Glupczynski Y
出版信息
Antimicrob Agents Chemother. 1986 Aug;30(2):258-9. doi: 10.1128/AAC.30.2.258.
Abstract
The rate of bactericidal activity of a new quinolone, CI-934, was compared with that of amoxicillin for 20 strains of Streptococcus faecalis. At 10 and 100 micrograms/ml, the bactericidal activity of CI-934 was more rapid at 6 h than that of amoxicillin. A paradoxical effect (a killing rate higher at 1 microgram/ml than at 100 micrograms/ml at 6 h) was observed for 19 of the 20 strains with amoxicillin and for 1 of the 20 strains with CI-934. It remains to be demonstrated whether in vivo studies will confirm the results obtained in vitro.
摘要
将新型喹诺酮类药物CI - 934与阿莫西林针对20株粪肠球菌的杀菌活性速率进行了比较。在浓度为10微克/毫升和100微克/毫升时，CI - 934在6小时时的杀菌活性比阿莫西林更快。在20株菌株中，有19株使用阿莫西林时观察到了矛盾效应（在6小时时，1微克/毫升的杀菌率高于100微克/毫升），而使用CI - 934的20株菌株中有1株出现此效应。体内研究是否会证实体外实验结果仍有待证明。
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