丙戊酰胺抑制人环氧水解酶。
Valpromide inhibits human epoxide hydrolase.
作者信息
Pacifici G M, Franchi M, Bencini C, Rane A
出版信息
Br J Clin Pharmacol. 1986 Sep;22(3):269-74. doi: 10.1111/j.1365-2125.1986.tb02886.x.
Abstract
The effect of antipileptic drug valpromide (VPM) on the activity of epoxide hydrolase was studied in human adult and foetal liver, kidneys, lungs, intestine and in placenta. The activity of the epoxide hydrolase was measured with both styrene oxide and benzo(a)pyrene-4,5-oxide as substrates. VPM inhibited the epoxide hydrolase obtained from all organs studied. The degree of inhibition was independent of the substrate used. A lowering of the epoxide hydrolase activity by 50% was observed when the concentration of VPM was similar to that of the substrates. VPM competitively inhibited the activity of adult liver epoxide hydrolase with styrene oxide as substrate.
摘要
研究了抗癫痫药物丙戊酰胺（VPM）对成人及胎儿肝脏、肾脏、肺、肠道和胎盘环氧水解酶活性的影响。以氧化苯乙烯和苯并（a）芘-4,5-氧化物为底物测定环氧水解酶的活性。VPM抑制了所研究的所有器官中的环氧水解酶。抑制程度与所用底物无关。当VPM浓度与底物浓度相似时，环氧水解酶活性降低了50%。以氧化苯乙烯为底物时，VPM竞争性抑制成人肝脏环氧水解酶的活性。
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