丙戊酰胺对卡马西平-10,11-环氧化物药代动力学的影响。
Effect of valpromide on the pharmacokinetics of carbamazepine-10, 11-epoxide.
作者信息
Pisani F, Fazio A, Oteri G, Spina E, Perucca E, Bertilsson L
机构信息
Neurology Clinic, University of Messina, Italy.
出版信息
Br J Clin Pharmacol. 1988 May;25(5):611-3. doi: 10.1111/j.1365-2125.1988.tb03354.x.
Abstract
The single oral dose pharmacokinetics of carbamazepine-10, 11-epoxide (CBZ-E) were investigated in six normal volunteers during a control session and during concurrent treatment with valpromide (VPM) (300 mg twice daily for 8 days). VPM caused a prolongation of the CBZ-E half-life from 6.4 +/- 1.4 to 20.5 +/- 6.3 h and decreased CBZ-E clearance from 73.5 +/- 20.0 to 23.5 +/- 4.0 ml h-1 kg-1 (P less than 0.01). These results suggest that the elevation of plasma CBZ-E levels in patients receiving carbamazepine and VPM in combination is due to inhibition of epoxide hydrolase in the liver.
摘要
在一次对照实验期间以及与丙戊酰胺（VPM）（每日两次，每次300毫克，共8天）联合治疗期间，对6名正常志愿者进行了卡马西平 - 10,11 - 环氧化物（CBZ - E）单次口服给药的药代动力学研究。VPM使CBZ - E半衰期从6.4±1.4小时延长至20.5±6.3小时，并使CBZ - E清除率从73.5±20.0毫升/小时·千克降至23.5±4.0毫升/小时·千克（P＜0.01）。这些结果表明，联合使用卡马西平和VPM的患者血浆CBZ - E水平升高是由于肝脏中环氧化物水解酶受到抑制。
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