Kumar Arun, Walia Gagandeep Kaur, Gupta Vipin, Sachdeva M P
Department of Anthropology, University of Delhi, New Delhi 110 007,
J Genet. 2019 Mar;98.
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in the liver without any history of chronic alcohol consumption. It encompasses a wide spectrum of diseases that range from simple steatosis to nonalcoholicsteatohepatitis. NAFLD is strongly associated with obesity, insulin resistance / type-2 diabetes mellitus and the metabolic syndrome. NAFLD is a complex disorder; environmental and genetic factors interact with NAFLD manifestation and determine its progression. In this review, an attempt was made to provide current information on the genetic variants of NAFLD in Asian populations. Literature search was performed by using PubMed, Medline and Google Scholar database. Candidate gene, validation and genomewide association studies (GWASs) were included in this review. A total of 41 studies fulfilled inclusion criteria of which 12 candidate gene studies exclusively focussed on the gene and 17 other studies on other important candidate genes such as , ,, , etc. reported significant association with NAFLD. Eight validation studies identified associations of variants on , , , , , , etc. with NAFLD. Thus, so far, four GWASs have been conducted in Asian population that reported , , and genes which were significantly associated with NAFLD. Findings indicate that , , , and genes emerge out to be the important biological markers associated with NAFLD.
非酒精性脂肪性肝病（NAFLD）的特征是肝脏中脂肪堆积，且无慢性饮酒史。它涵盖了从单纯性脂肪肝到非酒精性脂肪性肝炎等一系列广泛的疾病。NAFLD与肥胖、胰岛素抵抗/2型糖尿病以及代谢综合征密切相关。NAFLD是一种复杂的疾病；环境和遗传因素与NAFLD的表现相互作用并决定其进展。在本综述中，我们试图提供有关亚洲人群中NAFLD基因变异的最新信息。通过使用PubMed、Medline和谷歌学术数据库进行文献检索。本综述纳入了候选基因、验证和全基因组关联研究（GWAS）。共有41项研究符合纳入标准，其中12项候选基因研究专门聚焦于 基因，另外17项关于其他重要候选基因（如 、 、 、 等）的研究报告了与NAFLD的显著关联。八项验证研究确定了 、 、 、 、 、 等基因变异与NAFLD的关联。因此，到目前为止，在亚洲人群中已经进行了四项GWAS，报告了与NAFLD显著相关的 、 、 和 基因。研究结果表明， 、 、 、 和 基因是与NAFLD相关的重要生物标志物。
