John Jubi, Omanakuttan Vishnu K, T Aneeja, Suresh Cherumuttathu H, Jones Peter G, Hopf Henning
Chemical Sciences and Technology Division , CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST) , Thiruvananthapuram 695019 , India.
Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201002 , India.
J Org Chem. 2019 May 3;84(9):5957-5964. doi: 10.1021/acs.joc.9b00488. Epub 2019 Apr 16.
An efficacious, metal-free strategy has been developed for the synthesis of 4-aryl-3-(2 H)-furanones. The reaction proceeds via the nucleophilic addition of an active methylene compound to the aryne followed by ring closing of the adduct. The reaction proceeds under mild conditions, is applicable for gram-scale synthesis of 4-aryl-3-(2 H)-furanones, and is general for a range of substituted arynes and haloacetates.
已开发出一种有效的无金属策略用于合成4-芳基-3-(2H)-呋喃酮。该反应通过活性亚甲基化合物对芳炔的亲核加成，随后加合物闭环进行。该反应在温和条件下进行，适用于4-芳基-3-(2H)-呋喃酮的克级规模合成，并且对于一系列取代的芳炔和卤代乙酸酯具有通用性。
