Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, School of Public Health, Fudan University, Shanghai, 200032, China.
The Center for Disease Control and Prevention of Putuo District, Shanghai, 200333, China.
Chemosphere. 2019 Jul;226:351-359. doi: 10.1016/j.chemosphere.2019.03.159. Epub 2019 Mar 28.
Phthalates are widespread endocrine-disrupting chemicals (EDCs) that have been suggested to affect neurodevelopment. However, association between lactational exposure to phthalates and neurodevelopmental effects has rarely been reported in epidemiological studies. We conducted a pilot prospective study of 138 mother-infant pairs to evaluate whether lactational exposure to phthalates was associated with neurodevelopmental effects in infants. At baseline survey, the spot urine samples from both mothers and infants were collected for measuring ten metabolites of phthalates, and the food intake information of infants was assessed by the food-frequency questionnaire (FFQ). At the follow-up survey in 9 months of age, the neurodevelopmental Function of infants was assessed using the Ages and Stages Questionnaire Edition 3 (ASQ-3). Multivariate logistic regression models were used to calculate the odds ratio (OR) for delayed development according to the level of exposure to phthalates. Our results indicated that MnBP and MiBP were high in lactating infants and mothers. In the overall study population, most metabolites showed positive associations with delayed development of most ASQ-3 domains. In male, MMP, MEP, MiBP and MnBP but not DEHP metabolites were significantly associated with increased odds of delayed development of all domains. In female, most LMWP metabolites and the four oxidative metabolites of DEHP were significantly associated with increased odds of delayed development of most domains. In conclusion, we found a significant negative association between lactational exposure to phthalates and ASQ-3 domains. Some of the sex-specific observations warrant further investigation. The dietary source of lactational phthalates exposure may not the breast milk or infant formula but the complementary food.
邻苯二甲酸酯是广泛存在的内分泌干扰化学物质（EDCs），据认为它们会影响神经发育。然而，在流行病学研究中，很少有关于哺乳期暴露于邻苯二甲酸酯与神经发育影响之间的关联的报道。我们进行了一项 138 对母婴配对的前瞻性研究，以评估哺乳期暴露于邻苯二甲酸酯是否与婴儿的神经发育效应有关。在基线调查中，收集了母亲和婴儿的尿液样本，以测量 10 种邻苯二甲酸酯代谢物，并通过食物频率问卷（FFQ）评估婴儿的食物摄入量信息。在 9 个月大的随访调查中，使用年龄和阶段问卷第 3 版（ASQ-3）评估婴儿的神经发育功能。使用多变量逻辑回归模型，根据邻苯二甲酸酯暴露水平计算发育迟缓的比值比（OR）。我们的结果表明，哺乳期婴儿和母亲的 MnBP 和 MiBP 含量较高。在整个研究人群中，大多数代谢物与 ASQ-3 大多数领域的发育迟缓呈正相关。在男性中，MMP、MEP、MiBP 和 MnBP 但不是 DEHP 代谢物与所有领域发育迟缓的几率增加显著相关。在女性中，大多数 LMWP 代谢物和 DEHP 的四种氧化代谢物与大多数领域发育迟缓的几率增加显著相关。总之，我们发现哺乳期暴露于邻苯二甲酸酯与 ASQ-3 领域之间存在显著负相关。一些性别特异性观察结果值得进一步研究。哺乳期邻苯二甲酸酯暴露的饮食来源可能不是母乳或婴儿配方奶粉，而是补充食物。
