Population Health Sciences, University of Bristol, Bristol, UK.
Thorax. 2019 May;74(5):503-505. doi: 10.1136/thoraxjnl-2018-212203. Epub 2019 Apr 4.
The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).
毛细支气管炎与儿童喘息易感性之间的确切关联尚不清楚。我们评估了整个 2007 年英国出生队列中毛细支气管炎的病因和后来的喘息表型。所有在英格兰出生的婴儿在生命的第一年中因毛细支气管炎或尿路感染（UTI）住院，通过住院患者统计数据进行随访，以确定随后 8 年中喘息入院的风险和特征。与 UTI 相比，在我们的 21272 名儿童队列中，既往毛细支气管炎的喘息入院风险更高（风险比（RR）2.4），非呼吸道合胞病毒毛细支气管炎的风险更高（RR 3.1），且持续到迟发性喘息（RR 1.7）。
