Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, China
Postgrad Med J. 2019 Apr;95(1122):210-216. doi: 10.1136/postgradmedj-2019-136409. Epub 2019 Apr 4.
The incidence of acute myocardial infarction (AMI) has been increasing rapidly in recent years, seriously endangering human health. Cardiac biomarkers play critical roles in the diagnosis and prognosis of AMI. Troponin is a highly sensitive and specific biomarker for AMI diagnosis and can independently predict adverse cardiac events. Other biomarkers such as N-terminal B-type natriuretic peptide and C reactive protein are also valuable predictors of cardiovascular prognosis. Recently, several novel biomarkers have been identified for the diagnosis and risk assessment in patients with AMI. A multibiomarker approach can potentially enhance the diagnostic accuracy and provide more information for the early risk stratification of AMI. In this review, we will summarise the biomarkers discovered in recent years and focus on their diagnostic and prognostic value for patients with AMI.
近年来，急性心肌梗死（AMI）的发病率迅速上升，严重危害人类健康。心脏生物标志物在 AMI 的诊断和预后中起着关键作用。肌钙蛋白是诊断 AMI 的高度敏感和特异性生物标志物，可独立预测不良心脏事件。其他生物标志物，如 N 末端 B 型利钠肽和 C 反应蛋白，也是心血管预后的有价值的预测指标。最近，已经确定了一些用于诊断和评估 AMI 患者风险的新型生物标志物。多标志物方法可能会提高诊断的准确性，并为 AMI 的早期风险分层提供更多信息。在这篇综述中，我们将总结近年来发现的生物标志物，并重点介绍它们对 AMI 患者的诊断和预后价值。
