Feutren G, Papoz L, Assan R, Vialettes B, Pehuet M, Vexiau P, Durostu H, Rodier M, Sirmai J, Lallemand A
C R Acad Sci III. 1986;303(8):295-7.
The effect of cyclosporine was evaluated in a double blind placebo controlled trial in 122 recent onset insulin-dependent diabetics. A significantly higher incidence of complete remissions was observed in patients treated with cyclosporine than in those receiving placebo (respectively 24 and 5.8%). The effect was still more clear-cut in patients having presented the highest cyclosporine blood level (37%). These results which have been obtained with modest toxicity demonstrate that cyclosporine induces remission of insulin-dependent diabetes and prompt to set up new controlled trials to evaluate the duration of the effect obtained and the potential risks of the treatment.
在一项针对122例近期发病的胰岛素依赖型糖尿病患者的双盲安慰剂对照试验中，评估了环孢素的效果。与接受安慰剂的患者相比，接受环孢素治疗的患者完全缓解的发生率显著更高（分别为24%和5.8%）。在环孢素血药浓度最高的患者中，这种效果更为明显（37%）。这些在毒性较小的情况下获得的结果表明，环孢素可诱导胰岛素依赖型糖尿病缓解，并促使开展新的对照试验，以评估所获效果的持续时间及治疗的潜在风险。
