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BMC Public Health. 2017 Feb 21;17(1):220. doi: 10.1186/s12889-017-4091-4.
3
Gynecological cancers: A summary of published Indian data.妇科癌症：印度已发表数据综述
South Asian J Cancer. 2016 Jul-Sep;5(3):112-20. doi: 10.4103/2278-330X.187575.
4
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Lancet Infect Dis. 2016 Oct;16(10):1154-1168. doi: 10.1016/S1473-3099(16)30120-7. Epub 2016 Jun 28.
5
National- and state-level impact and cost-effectiveness of nonavalent HPV vaccination in the United States.美国九价人乳头瘤病毒疫苗接种的国家级和州级影响及成本效益
Proc Natl Acad Sci U S A. 2016 May 3;113(18):5107-12. doi: 10.1073/pnas.1515528113. Epub 2016 Apr 18.
6
American Society of Clinical Oncology Statement: Human Papillomavirus Vaccination for Cancer Prevention.美国临床肿瘤学会声明：人乳头瘤病毒疫苗接种预防癌症。
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7
Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.英国卵巢癌筛查协作试验（UKCTOCS）中的卵巢癌筛查与死亡率：一项随机对照试验
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8
Immunogenicity and HPV infection after one, two, and three doses of quadrivalent HPV vaccine in girls in India: a multicentre prospective cohort study.印度女孩接种一剂、两剂和三剂四价人乳头瘤病毒疫苗后的免疫原性和人乳头瘤病毒感染：一项多中心前瞻性队列研究
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9
HPV vaccination: The most pragmatic cervical cancer primary prevention strategy.人乳头瘤病毒疫苗接种：最切实可行的宫颈癌一级预防策略。
Int J Gynaecol Obstet. 2015 Oct;131 Suppl 1:S33-5. doi: 10.1016/j.ijgo.2015.02.014. Epub 2015 Feb 25.
10
HPV-FASTER: broadening the scope for prevention of HPV-related cancer.HPV-FASTER：扩大 HPV 相关癌症预防范围。
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妇科癌症——不断变化的模式

Gynecological Cancers-the Changing Paradigm.

作者信息

Rema P

机构信息

Division of Gynaeoncology, Regional Cancer Centre, Trivandrum, Kerala India.

出版信息

Indian J Surg Oncol. 2019 Mar;10(1):156-161. doi: 10.1007/s13193-018-0842-7. Epub 2018 Nov 29.

DOI:10.1007/s13193-018-0842-7
PMID:30948892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6414572/
Abstract

Outstanding research in the last few decades led to newer insights into the management of gynecological cancers. In the preventive arena, the efficacy and safety of HPV vaccination are well accepted and is now in addition to bi- and quadrivalent vaccines; there is a nonavalent vaccine against nine oncogenic HPV strains. Recent studies also looked into the dosaging schedules and age of vaccination against HPV to improve the vaccine efficacy and coverage. HPV testing is now approved as a primary screening test for cervical cancer in women aged more than 30 years with better sensitivity than the traditional cytology. Opportunistic salpingectomy for ovarian cancer prevention and neoadjuvant chemotherapy for advanced ovarian cancers are accepted practices. The role of personalized medicine in ovarian cancer and comprehensive genomic analysis of endometrial cancers are also covered in this review.

摘要

过去几十年的杰出研究为妇科癌症的管理带来了新的见解。在预防领域，HPV疫苗接种的有效性和安全性已得到广泛认可，目前除了二价和四价疫苗外，还有一种针对九种致癌HPV毒株的九价疫苗。最近的研究还探讨了HPV疫苗接种的剂量方案和接种年龄，以提高疫苗效力和覆盖率。HPV检测现已被批准作为30岁以上女性宫颈癌的主要筛查检测方法，其灵敏度高于传统细胞学检测。预防性输卵管切除术预防卵巢癌以及晚期卵巢癌的新辅助化疗已被广泛应用。本综述还涵盖了个性化医疗在卵巢癌中的作用以及子宫内膜癌的综合基因组分析。