Mathur Rachit, Singhavi Hitesh Rajendra, Malik Akshat, Nair Sudhir, Chaturvedi Pankaj
Dept. of Head and Neck Surgery, Tata Memorial Centre, Parel, Mumbai 400012 India.
Indian J Surg Oncol. 2019 Mar;10(1):184-195. doi: 10.1007/s13193-018-0836-5. Epub 2018 Dec 7.
Oral squamous cell carcinomas (OSCC) are among the commonest cancers in South East Asia and more so in the Indian subcontinent. The role of tobacco and alcohol in the causation of these cancers is well-documented. Poor oral hygiene (POH) is often seen to co-exist in patients with OSCC. However, the role of poor oral hygiene in the etio-pathogenesis of these cancers is controversial. We decided to evaluate the available literature for evaluating the association of POH with OSCC. A thorough literature search of English-language articles in MEDLINE, PubMed, Cochrane Database of Systematic Reviews, and Web of Science databases was conducted, and 93 relevant articles were short-listed. We found that POH was strongly associated with oral cancers. It aids the carcinogenic potential of other known carcinogens like tobacco and alcohol. Even on adjusting for known confounding factors like tobacco, alcohol use, education, and socio-economic strata, presence of POH exhibits higher odds of developing oral cancer.
口腔鳞状细胞癌(OSCC)是东南亚最常见的癌症之一,在印度次大陆更为常见。烟草和酒精在这些癌症病因中的作用已有充分记录。口腔卫生不良(POH)在OSCC患者中经常同时存在。然而,口腔卫生不良在这些癌症的病因发病机制中的作用存在争议。我们决定评估现有文献,以评估POH与OSCC的关联。我们对MEDLINE、PubMed、Cochrane系统评价数据库和科学网数据库中的英文文章进行了全面的文献检索,筛选出93篇相关文章。我们发现POH与口腔癌密切相关。它有助于烟草和酒精等其他已知致癌物的致癌潜力。即使在对烟草、酒精使用、教育程度和社会经济阶层等已知混杂因素进行调整后,POH的存在仍显示出患口腔癌的更高几率。