Romagnoli Enrico, Gatto Laura, Prati Francesco
Ospedale San Giovanni-Addolorata, Rome, Italy.
Centro per la Lotta contro l'Infarto-CLI Foundation, Rome, Italy.
Eur Heart J Suppl. 2019 Mar;21(Suppl B):B80-B83. doi: 10.1093/eurheartj/suz032. Epub 2019 Mar 29.
Atherosclerosis is a chronic degenerative disease, with a significant inflammatory component, characterized by phases of rapid activation leading to important clinical events, such as myocardial infarction. One of the major challenges of modern cardiology is limiting the progression of atherosclerotic disease and anticipating the phases of instability as to limit its consequences. In this contest modern techniques of intra-coronary imaging, such as optical coherence tomography, could have a pivotal role in identifying patients at higher risk of acute events in the short term. The purpose of the CLIMA study is to identify and map the vulnerability criteria of atherosclerotic coronary plaques in the individual patient, and provide a personalized risk score for coronary events.
动脉粥样硬化是一种慢性退行性疾病，具有显著的炎症成分，其特征是快速激活阶段会导致重要的临床事件，如心肌梗死。现代心脏病学的主要挑战之一是限制动脉粥样硬化疾病的进展，并预测不稳定阶段以限制其后果。在这种情况下，冠状动脉内成像的现代技术，如光学相干断层扫描，在识别短期内急性事件风险较高的患者方面可能具有关键作用。CLIMA研究的目的是识别并绘制个体患者动脉粥样硬化冠状动脉斑块的易损性标准，并为冠状动脉事件提供个性化风险评分。
