源自自发性小鼠胸腺瘤的新型双唾液酸神经节苷脂GD1c的结构
Structure of a new disialoganglioside GD1c from spontaneous murine thymoma.
作者信息
Bartoszewicz Z, Kościelak J, Pacuszka T
出版信息
Carbohydr Res. 1986 Aug 15;151:77-88. doi: 10.1016/s0008-6215(00)90331-8.
A major mono- and a di-sialoganglioside were isolated and purified to homogeneity from a spontaneous thymoma that occurs in AKR mice. Compositional and methylation analyses and the use of exoglycosidases established the monosialoganglioside to be alpha Neu(2----3)beta Gal(1----3)beta GalNAc(1----4)beta Gal(1----4)Glc(1----4)Cer and the disialoganglioside to be alpha NeuAc(2----8)alpha NeuAc(2----3)beta Gal(1----3)beta GalNAc(1----4)beta Gal(1----4)Glc(1----1)Cer (GD1c). A possible pathway for the biosynthesis of this disialoganglioside is presented.
从AKR小鼠发生的自发性胸腺瘤中分离并纯化出一种主要的单唾液酸神经节苷脂和一种二唾液酸神经节苷脂，使其达到同质状态。通过组成分析、甲基化分析以及外切糖苷酶的应用，确定单唾液酸神经节苷脂为α-Neu(2→3)β-Gal(1→3)β-GalNAc(1→4)β-Gal(1→4)Glc(1→4)Cer，二唾液酸神经节苷脂为α-NeuAc(2→8)α-NeuAc(2→3)β-Gal(1→3)β-GalNAc(1→4)β-Gal(1→4)Glc(1→1)Cer（GD1c）。本文提出了这种二唾液酸神经节苷脂生物合成的可能途径。
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