van Lambalgen A A, van den Bos G C, Bronsveld W, Thijs L G
Circ Shock. 1986;20(1):51-9.
In dogs anesthetized with etomidate (n = 8) or droperidol-methadone-atropine (n = 5), we measured before (t = 0) and after (t = 90 min) endotoxin (1.5 mg X kg-1 IV as a bolus) systemic and pulmonary blood pressures, cardiac output and its distribution (microspheres), blood gases, blood glucose, and lactate. The effects of endotoxin depended little on the type of anesthetic. The differences between the two groups were quantitative rather than qualitative. The influence of the type of anesthesia during endotoxin shock studies should thus not be overestimated.
在使用依托咪酯麻醉的犬（n = 8）或氟哌利多-美沙酮-阿托品麻醉的犬（n = 5）中，我们在静脉推注内毒素（1.5 mg·kg⁻¹）前（t = 0）和后（t = 90分钟）测量了体循环和肺循环血压、心输出量及其分布（微球法）、血气、血糖和乳酸。内毒素的作用几乎不依赖于麻醉类型。两组之间的差异是定量的而非定性的。因此，在内毒素休克研究中，不应高估麻醉类型的影响。
