Schaefer C F, Brackett D J, Tompkins P, Wilson M F
Circ Shock. 1984;12(2):125-33.
The influence of anesthesia on endotoxin shock patterns in the rat was examined. Blood pressure, heart rate, arterial blood gases, glucose, lactate, and pathology of the small intestine were measured before and after endotoxin (40 mg/kg) challenge in male Sprague-Dawley rats. The three groups studied were: (1) enflurane anesthetized (N = 10), (2) ketamine anesthetized (N = 10), and (3) awake and unrestrained (N = 13). Measurements were made during 30 min prior to endotoxin injection (IV) and for 240 min afterward. Reflex tachycardia, which occurred in the awake group simultaneously with the initial endotoxin-induced hypotension, was not present during either enflurane or ketamine anesthesia. Significantly less gross intestinal pathology was found at 4 hr after endotoxin in the anesthetized groups compared to the awake group. These results suggest that the response of the sympathoadrenal system to the hypotension following endotoxin may be blunted in the anesthetized animal.
研究了麻醉对大鼠内毒素休克模式的影响。在雄性Sprague-Dawley大鼠内毒素（40mg/kg）攻击前后，测量其血压、心率、动脉血气、葡萄糖、乳酸以及小肠病理学指标。所研究的三组分别为：（1）恩氟烷麻醉组（N = 10），（2）氯胺酮麻醉组（N = 10），以及（3）清醒且未束缚组（N = 13）。在内毒素注射（静脉注射）前30分钟及之后240分钟进行测量。清醒组在最初内毒素诱导的低血压同时出现的反射性心动过速，在恩氟烷或氯胺酮麻醉期间均未出现。与清醒组相比，麻醉组在内毒素攻击后4小时发现的肠道大体病理学改变明显较少。这些结果表明，在麻醉动物中，交感肾上腺系统对内毒素后低血压的反应可能会减弱。
