Nephrology and Dialysis Unit, Pediatric Subspecialties Department, Institute for Scientific Research, Bambino Gesù Children's Hospital, Piazza S. Onofrio 4, 00165, Rome, Italy.
Ege University Faculty of Medicine, Izmir, Turkey.
J Nephrol. 2019 Jun;32(3):445-451. doi: 10.1007/s40620-019-00606-1. Epub 2019 Apr 4.
The number of children with acute kidney injury (AKI) requiring dialysis is increasing. To date, systematic analysis has been largely limited to critically ill children treated with continuous renal replacement therapy (CRRT). We conducted a survey among 35 European Pediatric Nephrology Centers to investigate dialysis practices in European children with AKI. Altogether, the centers perform dialysis in more than 900 pediatric patients with AKI per year. PD and CRRT are the most frequently used dialysis modalities, accounting for 39.4% and 38.2% of treatments, followed by intermittent HD (22.4%). In units treating more than 25 cases per year and in those with cardiothoracic surgery programs, PD is the most commonly chosen dialysis modality. Also, nearly one quarter of centers, in countries with a gross domestic product below $35,000/year, do not utilize CRRT at all. Dialysis nurses are exclusively in charge of CRRT management in 45% of the cases and pediatric intensive care nurses in 25%, while shared management is practiced in 30%. In conclusion, this survey indicates that the choice of treatment modalities for dialysis in children with AKI in Europe is affected by the underlying ethiology of the disease, organization/set-up of centers and socioeconomic conditions. PD is utilized as often as CRRT, and also intermittent HD is a commonly applied treatment option. A prospective European AKI registry is planned to provide further insights on the epidemiology, management and outcomes of dialysis in pediatric AKI.
急性肾损伤(AKI)需要透析的儿童人数正在增加。迄今为止,系统分析在很大程度上仅限于接受连续肾脏替代治疗(CRRT)的危重症儿童。我们对 35 个欧洲儿科肾脏病中心进行了一项调查,以调查欧洲 AKI 儿童的透析实践。这些中心每年为超过 900 名 AKI 儿科患者进行透析。PD 和 CRRT 是最常用的透析方式,占治疗的 39.4%和 38.2%,其次是间歇性 HD(22.4%)。在每年治疗超过 25 例的单位和有心脏外科项目的单位中,PD 是最常选择的透析方式。此外,在国内生产总值低于 35000 美元/年的国家,近四分之一的中心根本不使用 CRRT。在 45%的病例中,透析护士专门负责 CRRT 管理,25%由儿科重症监护护士负责,30%由共同管理负责。总之,这项调查表明,欧洲儿童 AKI 透析治疗方式的选择受到疾病的潜在病因、中心的组织/设置和社会经济状况的影响。PD 的使用频率与 CRRT 相当,间歇性 HD 也是一种常用的治疗选择。计划建立一个前瞻性的欧洲 AKI 登记处,以进一步了解儿科 AKI 中透析的流行病学、管理和结果。