Department of Neurosurgery, University Hospital Zurich, University of Zurich, Switzerland.
Department of Neurology, University Hospital Zurich, University of Zurich, Switzerland / Cereneo, Centre for Neurology and Rehabilitation, Vitznau, Switzerland.
Swiss Med Wkly. 2019 Apr 5;149:w20062. doi: 10.4414/smw.2019.20062. eCollection 2019 Mar 25.
Among spontaneous intracranial haemorrhages, primary non-traumatic brainstem haemorrhages are associated with the highest mortality rate. Patients classically present with rapid neurological deterioration. Previous studies have found that the severity of initial neurological symptoms and hydrocephalus are predictors of poor outcomes. In addition, radiological parameters aim to classify brainstem haematomas according to volume, extension and impact on prognosis. However, previous studies have failed to agree on a differentiated radiological classification for outcome and functional recovery. Electrophysiology, including motor, auditory and somatosensory evoked potentials, is used to estimate the extent of the initial injury and predict functional recovery. The current management of brainstem haematomas remains conservative, focusing on initial close neurocritical care monitoring. Surgical treatment concepts exist, but similarly to general intracranial haemorrhage management, they continue to be controversial and have not been sufficiently investigated. This is especially the case for haematomas in the posterior fossa, as these are excluded from most current clinical trials. Existing studies were mostly carried out before the present millennium began, and limitations are evident in the adaptation of those results and recommendations to current management, with today’s technological and diagnostic possibilities. We therefore recommend the re-evaluation of brainstem haemorrhages in the modern neurosurgical and intensive care environment.
在自发性颅内出血中,原发性非创伤性脑干出血的死亡率最高。患者通常表现为迅速的神经功能恶化。先前的研究发现,初始神经症状的严重程度和脑积水是预后不良的预测因素。此外,影像学参数旨在根据体积、延伸范围和对预后的影响对脑干血肿进行分类。然而,先前的研究未能就预后和功能恢复的差异化影像学分类达成一致意见。电生理学,包括运动、听觉和体感诱发电位,用于估计初始损伤的程度并预测功能恢复。目前对脑干血肿的处理仍然是保守的,重点是初始密切的神经重症监护监测。存在手术治疗的概念,但与一般颅内出血的治疗一样,它们仍存在争议,且尚未得到充分研究。对于后颅窝的血肿尤其如此,因为这些血肿大多被排除在目前的大多数临床试验之外。现有的研究大多是在本世纪初之前进行的,这些结果和建议在适应当前的管理方面存在明显的局限性,因为当前的技术和诊断手段存在可能。因此,我们建议在现代神经外科和重症监护环境中重新评估脑干出血。