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[多哥的血管性皮肤异常:一项120例病例研究]

[Vascular Cutaneous Abnormalities in Togo: a 120-Case Study].

作者信息

Akakpo A S, Saka B, Téclessou J N, Djalogue L, Mahamadou G, Mouhari-Touré A, Gottara W Soga, Kombaté K, Tchangai-Walla K, Pitché P

机构信息

Service de dermatologie et IST, CHU Sylvanus-Olympio, université de Lomé, Togo.

Service de dermatologie et IST, CHU Campus, université de Lomé, Togo.

出版信息

Bull Soc Pathol Exot. 2018;111(5):278-282. doi: 10.3166/bspe-2019-0053.

Abstract

The purpose of this study was to describe the epidemio-clinical profile, and treatment of vascular cutaneous abnormalities in Togo. It was a retrospective study of patients recorded in dermatology for vascular cutaneous abnormality between 1998 and 2017. During the study period, 120 (0.1%) of 88,869 patients received in dermatology have consulted for vascular cutaneous abnormalities. Their mean age was 25.3 months and the sex-ratio (M/F) 0.4. The most recurring vascular cutaneous abnormalities were vascular tumors (97 cases; 80.8%), mainly infantile hemangioma (IH) (93 cases; 77.5%). The mean time of onset of IH after birth was 2.9 months. The IH (54 cases; 50.5%) and port wine stains (8 cases, 53.3%) were predominantly localized at the cephalic region and Klippel-Trenaunay syndrome cases on lower limbs. We opted for a therapeutic abstention in the majority of the patients (50 cases of IH, 16 cases of simple vascular abnormalities, all Klippel-Trenaunay syndrome cases and telegiectasia cases). Of the 43 IH cases treated, the main drugs used were corticosteroids (23 cases of which 17 between 1998 and 2011 and 6 from 2012) followed by propranolol (11 cases from 2012). We had a favorable response in 9 of the 15 patients seen again. Cutaneous vascular abnormalities are very rare in dermatology in Togo and are dominated by IH with female predominance. In IH treatments, propranolol use, started in 2012 in Togo, is increasing when corticotherapy has declined.

摘要

本研究旨在描述多哥血管性皮肤异常的流行病学临床特征及治疗情况。这是一项对1998年至2017年皮肤科记录的血管性皮肤异常患者的回顾性研究。在研究期间,皮肤科收治的88869例患者中有120例(0.1%)因血管性皮肤异常前来就诊。他们的平均年龄为25.3个月,性别比(男/女)为0.4。最常见的血管性皮肤异常是血管肿瘤(97例;80.8%),主要是婴儿血管瘤(IH)(93例;77.5%)。IH出生后的平均发病时间为2.9个月。IH(54例;50.5%)和葡萄酒色斑(8例,53.3%)主要位于头部区域,而Klippel-Trenaunay综合征病例则位于下肢。我们对大多数患者(50例IH、16例单纯血管异常、所有Klippel-Trenaunay综合征病例和毛细血管扩张病例)选择了观察等待的治疗方式。在43例接受治疗的IH病例中,主要使用的药物是皮质类固醇(23例,其中1998年至2011年有17例,2012年有6例),其次是普萘洛尔(2012年有11例)。在15例复诊患者中,有9例反应良好。多哥皮肤科中皮肤血管异常非常罕见,以女性为主的IH占主导。在IH治疗中,多哥于2012年开始使用的普萘洛尔的使用量在皮质类固醇疗法减少时呈上升趋势。

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