Department of Dermatology, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
J Cosmet Dermatol. 2023 Dec;22(12):3369-3374. doi: 10.1111/jocd.15823. Epub 2023 Jun 14.
Infantile hepatic hemangioma (IHH) is a common liver tumor in infants and shares the same characteristics as cutaneous infantile hemangioma (IH). Propranolol is effective for symptomatic IHH. The clinical features between cutaneous IH and IHH, and treatment efficacy of IHH (smaller than 4 cm) is unclear. To evaluate the correlation of clinical features between cutaneous IH and IHH, as well as efficacy of systemic propranolol in the treatment of cutaneous IH combined with IHH.
The clinical data of infants with complicated cutaneous IH combined with IHH treated with systemic propranolol (1.5 ~ 2 mg/(kg d)) from January 2011 to October 2020 were retrospectively analyzed.
Forty-five cases with IHH combined with complicated cutaneous IH were reviewed. Single cutaneous IH is more likely to be combined with focal IHH, cutaneous IH greater than 5, more likely to be combined with multiple IHH (Pearson = 0.546, p < 0.01). The mean age of focal and multiple IHH regression was 11.93 ± 14.42 months and 10.20 ± 9.15 months, respectively.
The number of cutaneous IH were correlated with the number of IHH. There was no difference in the age of complete remission for focal and multiple IHH.
婴儿肝脏血管瘤（IHH）是婴儿期常见的肝脏肿瘤，与皮肤婴儿血管瘤（IH）具有相同的特征。普萘洛尔对有症状的 IHH 有效。皮肤 IH 和 IHH 之间的临床特征以及 IHH（小于 4cm）的治疗效果尚不清楚。为了评估皮肤 IH 和 IHH 之间的临床特征相关性，以及全身应用普萘洛尔治疗皮肤 IH 合并 IHH 的疗效。
回顾性分析了 2011 年 1 月至 2020 年 10 月期间接受全身普萘洛尔（1.5~2mg/（kg·d））治疗的合并复杂皮肤 IH 的婴儿的临床资料。
共回顾了 45 例 IHH 合并复杂皮肤 IH 的病例。单发皮肤 IH 更可能合并局灶性 IHH，皮肤 IH 大于 5cm 更可能合并多发 IHH（Pearson=0.546，p<0.01）。局灶性和多发性 IHH 消退的平均年龄分别为 11.93±14.42 个月和 10.20±9.15 个月。
皮肤 IH 的数量与 IHH 的数量有关。局灶性和多发性 IHH 完全缓解的年龄无差异。
