Bohdanecká M, Schück O
Czech Med. 1986;9(3):157-61.
Internal distribution of 2-sulphanilamido-5-methoxypyrimidine (SM) 100 mg/kg in rats is characterized by a corticopapillary gradient. The papilla/cortex ratio of SM concentration averaged 2.25 +/- 0.34. Furosemide (5 mg/kg) elicited a significant corticopapillary gradient decrease for SM. Corticopapillary gradients for SM and sodium showed a positive correlation (r = 0.45; p less than 0.001). After furosemide corticopapillary gradient for SM averaged 1.4 +/- 0.22. Unilateral nephrectomy alone induced no significant difference in the corticopapillary gradient for SM compared with controls. Corticopapillary gradient for SM was significantly lower in unilaterally nephrectomized rats than in controls when furosemide was given after 24 hours or 7 or 14 days. The results suggest that SM concentration was significantly higher in the medulla than in the cortex; furosemide led to a significant decrease of corticopapillary gradient for SM against controls; the corticopapillary gradient for SM did not significantly change after unilateral nephrectomy; the effect of furosemide on corticopapillary gradient for SM was more pronounced in rats after unilateral nephrectomy than in controls.
大鼠体内2-磺胺氨基-5-甲氧基嘧啶（SM）100毫克/千克的内部分布具有皮质-乳头梯度特征。SM浓度的乳头/皮质比平均为2.25±0.34。呋塞米（5毫克/千克）使SM的皮质-乳头梯度显著降低。SM和钠的皮质-乳头梯度呈正相关（r = 0.45；p＜0.001）。呋塞米给药后，SM的皮质-乳头梯度平均为1.4±0.22。单独进行单侧肾切除与对照组相比，SM的皮质-乳头梯度无显著差异。当在24小时、7天或14天后给予呋塞米时，单侧肾切除大鼠的SM皮质-乳头梯度显著低于对照组。结果表明，髓质中SM浓度显著高于皮质；呋塞米导致SM的皮质-乳头梯度相对于对照组显著降低；单侧肾切除后SM的皮质-乳头梯度无显著变化；呋塞米对单侧肾切除大鼠SM皮质-乳头梯度的影响比对对照组更明显。
