Holá V, Polívková L, Novák L
Czech Med. 1986;9(3):166-9.
The first pharmacokinetic data are reported of azlocillin injected intramuscularly to adult probands. The blood serum and urinary levels of azlocillin were determined microbiologically in 8 healthy volunteers after intramuscular injection of 2 grams. Peak serum levels of azlocillin were found by the end of hour 1 after injection, average level was (55.06 +/- 10.25) mg/l. At hour 2 the average level was (33.64 +/- 6.46) mg/l. and at hour 4, (9.47 +/- 1.79) mg/l. The biological half-life was 1.4 hour. In urine, (41.2 +/- 7.7)% of the administered dose was eliminated within 8 hours on average.
首次报道了对成年受试者肌内注射阿洛西林后的药代动力学数据。在8名健康志愿者肌内注射2克阿洛西林后，采用微生物学方法测定了血清和尿液中阿洛西林的水平。注射后1小时末测得阿洛西林血清峰值水平，平均水平为(55.06±10.25)毫克/升。2小时时平均水平为(33.64±6.46)毫克/升，4小时时为(9.47±1.79)毫克/升。生物半衰期为1.4小时。尿液中，平均8小时内消除了给药剂量的(41.2±7.7)%。
