Voigt R, Weidt I, Schröder S, Brandstädt A, Peiker G
Klinik für Frauenheilkunde und Geburtshilfe, Bereichs Medizin, Friedrich-Schiller-Universität Jena.
Zentralbl Gynakol. 1988;110(15):944-8.
Examining serum level values and urinary concentrations taken from non-pregnant control persons and pregnant women suffering from urinary tract infections (UTI) during the III. trimenon, the pharmacokinetic dates after single and repeated applications of 4 g azlocillin have been evaluated. We used a computer program based on the two-compartment model. It is shown that during pregnancy complicated by UTI the elimination half-life time will be prolonged and returns after therapy nearly to normal values. The results, discussed with the dates given by literature, allow us to state that it is not necessary to change dosage and application interval of azlocillin during pregnancy.
通过检测非妊娠对照人群以及妊娠晚期患有尿路感染（UTI）的孕妇的血清水平值和尿液浓度，评估了单次及重复应用4g阿洛西林后的药代动力学数据。我们使用了基于二室模型的计算机程序。结果表明，在并发UTI的妊娠期，消除半衰期会延长，治疗后几乎恢复到正常水平。结合文献给出的数据对结果进行讨论后，我们可以得出结论：妊娠期无需改变阿洛西林的剂量和用药间隔。
